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(Top) 1 Interactions 2 References 3 Further reading

PPP6C

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PPP6C

Identifiers

Aliases

PPP6C, PP6, PP6C, protein phosphatase 6 catalytic subunit

External IDs

OMIM: 612725; MGI: 1915107; HomoloGene: 68273; GeneCards: PPP6C; OMA:PPP6C - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q33.3	Start	125,146,573 bp^[1]
Band	9q33.3	End	125,189,939 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 B	Start	39,084,366 bp^[2]
Band	2\|2 B	End	39,116,463 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

sperm

secondary oocyte

gingival epithelium

parotid gland

buccal mucosa cell

palpebral conjunctiva

amniotic fluid

deltoid muscle

epithelium of nasopharynx

Top expressed in

medullary collecting duct

tail of embryo

genital tubercle

renal corpuscle

triceps brachii muscle

endocardial cushion

vastus lateralis muscle

spermatid

temporal muscle

morula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding phosphoprotein phosphatase activity hydrolase activity metal ion binding protein serine/threonine phosphatase activity
Cellular component	cytoplasm cytosol Golgi membrane mitochondrion
Biological process	cell cycle COPII vesicle coating protein dephosphorylation immune system process innate immune response G1/S transition of mitotic cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5537


67857

Ensembl


ENSG00000119414


ENSMUSG00000026753

UniProt


O00743


Q9CQR6

RefSeq (mRNA)


NM_001123355 NM_001123369 NM_002721


NM_024209

RefSeq (protein)


NP_001116827 NP_001116841 NP_002712


NP_077171

Location (UCSC)

Chr 9: 125.15 – 125.19 Mb

Chr 2: 39.08 – 39.12 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein phosphatase 6 catalytic subunit is an enzyme that in humans is encoded by the PPP6C gene.^[5]^[6]

Interactions[edit]

PPP6C has been shown to interact with IGBP1.^[7]^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119414 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026753 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Bastians H, Krebber H, Vetrie D, Hoheisel J, Lichter P, Ponstingl H, Joos S (April 1997). "Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3". Genomics. 41 (2): 296–7. doi:10.1006/geno.1997.4640. PMID 9143513.

^ "Entrez Gene: PPP6C protein phosphatase 6, catalytic subunit".

^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, et al. (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

^ Chen J, Peterson RT, Schreiber SL (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.

Further reading[edit]

Bastians H, Ponstingl H (December 1996). "The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation". Journal of Cell Science. 109 ( Pt 12) (Pt 12): 2865–74. doi:10.1242/jcs.109.12.2865. PMID 9013334.

Chen J, Peterson RT, Schreiber SL (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.

Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.

Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.

Nasu-Nishimura Y, Hayashi T, Ohishi T, Okabe T, Ohwada S, Hasegawa Y, et al. (June 2006). "Role of the Rho GTPase-activating protein RICS in neurite outgrowth". Genes to Cells. 11 (6): 607–14. doi:10.1111/j.1365-2443.2006.00966.x. PMID 16716191. S2CID 7935936.

Stefansson B, Brautigan DL (August 2006). "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon". The Journal of Biological Chemistry. 281 (32): 22624–34. doi:10.1074/jbc.M601772200. PMID 16769727.

Stefansson B, Brautigan DL (June 2007). "Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells". Cell Cycle. 6 (11): 1386–92. doi:10.4161/cc.6.11.4276. PMID 17568194.

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