Contents

PRKCH

Protein-coding gene in the species Homo sapiens

PRKCH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FK9, 3TXO
Identifiers
Aliases	PRKCH, PKC-L, PKCL, PRKCL, nPKC-eta, protein kinase C eta
External IDs	OMIM: 605437; MGI: 97600; HomoloGene: 84384; GeneCards: PRKCH; OMA:PRKCH - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.1 Start 61,187,559 bp[1] End 61,550,976 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 73,631,570 bp[2] End 73,824,959 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland granulocyte blood lymph node tonsil upper lobe of left lung thymus right lung visceral pleura epithelium of colon Top expressed in right lung lobe esophagus hair follicle gastrula endothelial cell of lymphatic vessel transitional epithelium of urinary bladder blood thymus lip nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein kinase C activity metal ion binding kinase activity protein serine/threonine kinase activity calcium-independent protein kinase C activity enzyme binding ATP binding protein binding Cellular component cytoplasm cytosol membrane cell-cell junction plasma membrane extracellular exosome intracellular anatomical structure Biological process positive regulation of B cell receptor signaling pathway cell differentiation intracellular signal transduction phosphorylation regulation of bicellular tight junction assembly positive regulation of keratinocyte differentiation negative regulation of glial cell apoptotic process protein kinase C signaling platelet activation protein phosphorylation positive regulation of macrophage derived foam cell differentiation positive regulation of NF-kappaB transcription factor activity peptidyl-serine phosphorylation positive regulation of glial cell proliferation signal transduction positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5583 18755 Ensembl ENSG00000027075 ENSMUSG00000021108 UniProt P24723 P23298 RefSeq (mRNA) NM_006255 NM_008856 NM_001313977 RefSeq (protein) NP_006246 NP_001300906 NP_032882 Location (UCSC) Chr 14: 61.19 – 61.55 Mb Chr 12: 73.63 – 73.82 Mb PubMed search [3] [4]
Wikidata
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Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.^[5][6][7]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.^[7]

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