Contents

PTPN2

Protein-coding gene in the species Homo sapiens

PTPN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L8K
Identifiers
Aliases	PTPN2, PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP, protein tyrosine phosphatase, non-receptor type 2, protein tyrosine phosphatase non-receptor type 2
External IDs	OMIM: 176887; MGI: 97806; HomoloGene: 7497; GeneCards: PTPN2; OMA:PTPN2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.21 Start 12,785,478 bp[1] End 12,929,643 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 67,798,581 bp[2] End 67,857,665 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii monocyte granulocyte tonsil cartilage tissue parotid gland oocyte lymph node body of pancreas gonad Top expressed in otic placode saccule condyle primary oocyte fossa Paneth cell hair follicle secondary oocyte submandibular gland primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein kinase binding phosphatase activity integrin binding phosphoprotein phosphatase activity syntaxin binding non-membrane spanning protein tyrosine phosphatase activity receptor tyrosine kinase binding hydrolase activity protein tyrosine phosphatase activity STAT family protein binding Cellular component cytoplasm membrane plasma membrane endoplasmic reticulum nucleus endoplasmic reticulum-Golgi intermediate compartment nucleoplasm cytosol Biological process negative regulation of type I interferon-mediated signaling pathway negative regulation of epidermal growth factor receptor signaling pathway positive regulation of PERK-mediated unfolded protein response dephosphorylation negative regulation of interleukin-4-mediated signaling pathway positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of interleukin-6-mediated signaling pathway negative regulation of cell population proliferation protein dephosphorylation negative regulation of interleukin-2-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway negative regulation of protein tyrosine kinase activity regulation of hepatocyte growth factor receptor signaling pathway negative regulation of platelet-derived growth factor receptor-beta signaling pathway insulin receptor signaling pathway negative regulation of interferon-gamma-mediated signaling pathway glucose homeostasis negative regulation of chemotaxis negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of macrophage differentiation negative regulation of T cell receptor signaling pathway negative regulation of positive thymic T cell selection negative regulation of insulin receptor signaling pathway T cell differentiation negative regulation of ERK1 and ERK2 cascade erythrocyte differentiation negative regulation of lipid storage B cell differentiation peptidyl-tyrosine dephosphorylation positive regulation of gluconeogenesis negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of inflammatory response negative regulation of transcription by RNA polymerase II negative regulation of tyrosine phosphorylation of STAT protein cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5771 19255 Ensembl ENSG00000175354 ENSMUSG00000024539 UniProt P17706 Q06180 RefSeq (mRNA) NM_001207013 NM_001308287 NM_002828 NM_080422 NM_080423 NM_001127177 NM_008977 RefSeq (protein) NP_001193942 NP_001295216 NP_002819 NP_536347 NP_536348 NP_001120649 NP_033003 Location (UCSC) Chr 18: 12.79 – 12.93 Mb Chr 18: 67.8 – 67.86 Mb PubMed search [3] [4]
Wikidata
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Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.^[5][6]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described.

The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.^[6]

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Further reading[edit]

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