Paul Alan Marks (August 16, 1926 – April 28, 2020) was a medical doctor, researcher and administrator. He was a faculty member and president at Memorial Sloan Kettering Cancer Center.[1][2]
Marks was born in Mahanoy City, Pennsylvania, in 1926, to Robert Marks and Sarah Bohorad.[3] Marks attended Columbia College and Columbia Medical School. After completing postdoctoral research at the United States National Institutes of Health and at the Institut PasteurinFrance, he joined the faculty at Columbia University. Marks served as dean of the Medical Faculty at Columbia University from 1970 to 1973.[4] He was president and chief executive officer at Memorial Sloan Kettering from 1980 until 1999.[4] Marks died at his Manhattan home from pulmonary fibrosis and lung cancer on April 28, 2020, at the age of 93. [3]
Marks contributed to the fields of genetics and oncology.[4] His recent work was focused on histone deacetylases (HDACs) and chemicals that interfere with HDAC enzymatic activities (HDAC inhibitors or HDIs). Marks and others found that drugs such as Trichostatin A and SAHA (vorinostat) can serve as anticancer agents.[5]
The Paul Marks Prize for Cancer Research was established by Memorial Sloan Kettering to honor Marks's contributions "as a distinguished scientist and leader".[4] The prize has been awarded every two years since 2001.
^Marks, P. A.; Breslow, R. (2007). "Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug". Nature Biotechnology. 25 (1): 84–90. doi:10.1038/nbt1272. PMID17211407. S2CID12656582.
