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Other names | Aureolic acid; Mithracin; Antibiotic LA 7017; Mithramycin A; Mitramycin; Plicatomycin |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Routes of administration | Intravenous |
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ECHA InfoCard | 100.162.065 |
Chemical and physical data | |
Formula | C52H76O24 |
Molar mass | 1085.156 g·mol−1 |
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NY (what is this?) (verify) |
Plicamycin (INN, also known as mithramycin; trade name Mithracin) is an antineoplastic antibiotic produced by Streptomyces plicatus. It is an RNA synthesis inhibitor.[1] The manufacturer discontinued production in 2000. Several different structures are currently reported in different places all with the same chromomycin core, but with different stereochemistry in the glycoside chain, a 1999 study has re-investigated the compound and proposed a revised structure.[2]
Plicamycin has been used in the treatment of testicular cancer,[3][4] Paget's disease of bone,[5][6] and, rarely, the management of hypercalcemia.
Plicamycin has been tested in chronic myeloid leukemia.[7]
Plicamycin is currently used in multiple areas of research, including cancer cell apoptosis[8] and as a metastasis inhibitor.[9]
One elucidated pathway shows it interacts by cross-binding chromatin GC-rich promoter motifs, thereby inhibiting gene transcription.[10]
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CARTooltip Constitutive androstane receptor |
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PXRTooltip Pregnane X receptor |
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