| polypyrimidine tract binding protein 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PTBP1 | ||||||
| Alt. symbols | PTB | ||||||
| NCBI gene | 5725 | ||||||
| HGNC | 9583 | ||||||
| OMIM | 600693 | ||||||
| RefSeq | NM_002819 | ||||||
| UniProt | P26599 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.3 | ||||||
| |||||||
| polypyrimidine tract binding protein 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PTBP2 | ||||||
| NCBI gene | 58155 | ||||||
| HGNC | 17662 | ||||||
| OMIM | 608449 | ||||||
| RefSeq | NM_021190 | ||||||
| UniProt | Q9UKA9 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p21.3-22.1 | ||||||
| |||||||
Polypyrimidine tract-binding protein, also known as PTBorhnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization.[1] Two 2020 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional neurons.[2][3] These studies also show that such a treatment can be applied to the substantia nigra of mice models of Parkinson's disease in order to convert astrocytes to dopaminergic neurons and as a consequence restore motor function in these mice.
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