J u m p t o c o n t e n t
M a i n m e n u
M a i n m e n u
N a v i g a t i o n
● M a i n p a g e ● C o n t e n t s ● C u r r e n t e v e n t s ● R a n d o m a r t i c l e ● A b o u t W i k i p e d i a ● C o n t a c t u s ● D o n a t e
C o n t r i b u t e
● H e l p ● L e a r n t o e d i t ● C o m m u n i t y p o r t a l ● R e c e n t c h a n g e s ● U p l o a d f i l e
S e a r c h
Search
A p p e a r a n c e
● C r e a t e a c c o u n t ● L o g i n
P e r s o n a l t o o l s
● C r e a t e a c c o u n t ● L o g i n
P a g e s f o r l o g g e d o u t e d i t o r s l e a r n m o r e ● C o n t r i b u t i o n s ● T a l k
( T o p )
1 S i g n s a n d s y m p t o m s
2 C a u s e s
3 D i a g n o s i s
4 T r e a t m e n t
5 S e e a l s o
6 R e f e r e n c e s
7 E x t e r n a l l i n k s
T o g g l e t h e t a b l e o f c o n t e n t s
P u r e r e d c e l l a p l a s i a
9 l a n g u a g e s
● ا ل ع ر ب ي ة ● B o s a n s k i ● D e u t s c h ● E e s t i ● ف ا ر س ی ● I t a l i a n o ● L i e t u v i ų ● 日 本 語 ● T ü r k ç e
E d i t l i n k s
● A r t i c l e ● T a l k
E n g l i s h
● R e a d ● E d i t ● V i e w h i s t o r y
T o o l s
T o o l s
A c t i o n s
● R e a d ● E d i t ● V i e w h i s t o r y
G e n e r a l
● W h a t l i n k s h e r e ● R e l a t e d c h a n g e s ● U p l o a d f i l e ● S p e c i a l p a g e s ● P e r m a n e n t l i n k ● P a g e i n f o r m a t i o n ● C i t e t h i s p a g e ● G e t s h o r t e n e d U R L ● D o w n l o a d Q R c o d e ● W i k i d a t a i t e m
P r i n t / e x p o r t
● D o w n l o a d a s P D F ● P r i n t a b l e v e r s i o n
A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Pure red cell aplasia (PRCA ) or erythroblastopenia refers to a type of aplastic anemia affecting the precursors to red blood cells but usually not to white blood cells . In PRCA, the bone marrow ceases to produce red blood cells. There are multiple etiologies that can cause PRCA. The condition has been first described by Paul Kaznelson in 1922.[1]
Signs and symptoms
[ edit ]
Signs and symptoms may include:
Pale appearance
Rapid heart rate
Fatigue
Causes
[ edit ]
Causes of PRCA include:
Thymoma .[2]
Viral infections such as HIV , herpes , parvovirus B19 (Fifth disease ),[3] or hepatitis .[citation needed
Lymphoproliferative . Association of pure red cell aplasia with T-cell large granular lymphocyte leukemia is well recognized, especially in China.[4]
Idiopathic . Many cases of PRCA are considered idiopathic in that there is no discernible cause detected.[5]
Drugs such as mycophenolic acid [6] or erythropoietin .[7] [citation needed
Congenital . The term "hereditary pure red cell aplasia" has been used to refer to Diamond–Blackfan anemia .[8]
Diagnosis
[ edit ]
This section is empty. You can help by
adding to it .
(February 2024 )
Treatment
[ edit ]
PRCA is considered an autoimmune disease as it will respond to immunosuppressant treatment such as cyclosporin in many patients,[9] [10]
It has also been shown to respond to treatments with rituximab and tacrolimus .[citation needed
For cases related to B19 parvovirus, administration of commercial immunoglobulin can treat or cure parvovirus by replacing neutralizing antibodies.[11]
See also
[ edit ]
References
[ edit ]
^ Geetha D, Zachary JB, Baldado HM, Kronz JD, Kraus ES (December 2000). "Pure red cell aplasia caused by Parvovirus B19 infection in solid organ transplant recipients: a case report and review of literature". Clinical Transplantation . 14 6 ): 586–91. doi :10.1034/j.1399-0012.2000.140612.x . PMID 11127313 . S2CID 39011566 .
^ Kwong YL, Wong KF (1998). "Association of pure red cell aplasia with T large granular lymphocyte leukaemia" . J. Clin. Pathol . 51 9 ): 672–5. doi :10.1136/jcp.51.9.672 . PMC 500904 PMID 9930071 .
^ Miller AC, Rashid RM (2008). "Three episodes of acquired pure red cell aplasia restricted to pregnancy". Journal of Perinatal Medicine . 36 3 ): 270–1. doi :10.1515/JPM.2008.041 . PMID 18576941 .
^ Petrochko C (2009). "FDA Strengthens Warning on Transplant Drug." Medpage Today. 14 August 2009. Accessed 19 August 2009.
^ Macdougall, IC (November 2007). "Epoetin-induced pure red cell aplasia: diagnosis and treatment". Current Opinion in Nephrology and Hypertension . 16 6 ): 585–8. doi :10.1097/MNH.0b013e3282f0c4bf . PMID 18089975 . S2CID 24613046 .
^ Online Mendelian Inheritance in Man (OMIM): 105650
^ Sawada K, Hirokawa M, Fujishima N, et al. (August 2007). "Long-term outcome of patients with acquired primary idiopathic pure red cell aplasia receiving cyclosporine A. A nationwide cohort study in Japan for the PRCA Collaborative Study Group" . Haematologica . 92 8 ): 1021–8. doi :10.3324/haematol.11192 PMID 17640861 .
^ Sawada K, Fujishima N, Hirokawa M (August 2008). "Acquired pure red cell aplasia: updated review of treatment" . Br. J. Haematol . 142 (4 ): 505–14. doi :10.1111/j.1365-2141.2008.07216.x . PMC 2592349 PMID 18510682 .
^ National Organization for Rare Disorders. (2003). Nord Guide to Rare Disorders. Lippincott Williams & Wilkins.
External links
[ edit ]
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Pure_red_cell_aplasia&oldid=1210938812 " C a t e g o r y : ● A p l a s t i c a n e m i a s H i d d e n c a t e g o r i e s : ● U s e d m y d a t e s f r o m J u n e 2 0 2 0 ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n i s d i f f e r e n t f r o m W i k i d a t a ● A l l a r t i c l e s w i t h u n s o u r c e d s t a t e m e n t s ● A r t i c l e s w i t h u n s o u r c e d s t a t e m e n t s f r o m N o v e m b e r 2 0 1 0 ● A r t i c l e s w i t h u n s o u r c e d s t a t e m e n t s f r o m A p r i l 2 0 1 4 ● A r t i c l e s t o b e e x p a n d e d f r o m F e b r u a r y 2 0 2 4 ● A l l a r t i c l e s t o b e e x p a n d e d ● A r t i c l e s w i t h e m p t y s e c t i o n s f r o m F e b r u a r y 2 0 2 4 ● A l l a r t i c l e s w i t h e m p t y s e c t i o n s ● A r t i c l e s u s i n g s m a l l m e s s a g e b o x e s ● A r t i c l e s w i t h u n s o u r c e d s t a t e m e n t s f r o m A p r i l 2 0 1 7
● T h i s p a g e w a s l a s t e d i t e d o n 2 9 F e b r u a r y 2 0 2 4 , a t 0 1 : 4 2 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
![[icon]](https://akarinohon.com/text/taketori.cgi/en.wikipedia.org/wiki/File:Wiki_letter_w_cropped.svg){kind=small}
