Contents

RHOBTB1

Protein-coding gene in the species Homo sapiens

RHOBTB1
Identifiers
Aliases	RHOBTB1, Rho related BTB domain containing 1
External IDs	OMIM: 607351; MGI: 1916538; HomoloGene: 8892; GeneCards: RHOBTB1; OMA:RHOBTB1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q21.2 Start 60,869,438 bp[1] End 61,001,440 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B5.3 Start 68,987,264 bp[2] End 69,127,621 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vastus lateralis muscle Skeletal muscle tissue of rectus abdominis Achilles tendon muscle of thigh biceps brachii right uterine tube placenta Skeletal muscle tissue of biceps brachii cardia glutes Top expressed in myocardium of ventricle internal carotid artery cumulus cell aortic valve ascending aorta external carotid artery ureter islet of Langerhans otolith organ utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding GTPase activity protein kinase binding Cellular component cytosol plasma membrane intracellular anatomical structure cytoplasm cytoskeleton cell projection Biological process regulation of small GTPase mediated signal transduction small GTPase mediated signal transduction cell morphogenesis actin filament organization Rho protein signal transduction cell migration actin cytoskeleton organization positive regulation of actin filament polymerization actin cytoskeleton reorganization engulfment of apoptotic cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9886 69288 Ensembl ENSG00000072422 ENSMUSG00000019944 UniProt O94844 Q9DAK3 RefSeq (mRNA) NM_001242359 NM_014836 NM_001350902 NM_001350903 NM_001350904 NM_001350905 NM_001350906 NM_001350907 NM_001350908 NM_001350909 NM_001350910 NM_001350911 NM_001081347 NM_001252636 NM_001252637 NM_001252638 RefSeq (protein) NP_001229288 NP_055651 NP_001337831 NP_001337832 NP_001337833 NP_001337834 NP_001337835 NP_001337836 NP_001337837 NP_001337838 NP_001337839 NP_001337840 NP_001229288.1 NP_055651.1 NP_001074816 NP_001239565 NP_001239566 NP_001239567 Location (UCSC) Chr 10: 60.87 – 61 Mb Chr 10: 68.99 – 69.13 Mb PubMed search [3] [4]
Wikidata
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Rho-related BTB domain-containing protein 1 is a protein that in humans is encoded by the RHOBTB1 gene.^[5][6]

The protein encoded by this gene belongs to the Rho family of the Ras superfamily of small GTPases. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate transcriptional splice variants have been characterized.^[6]

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