![]() | |
Identifiers | |
---|---|
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C22H20F5N3O3 |
Molar mass | 469.412 g·mol−1 |
3D model (JSmol) | |
| |
|
RO4929097 (RG-4733) is a gamma secretase inhibitor being studied as an anti-cancer drug.[1] Targeting gamma secretase inhibits NOTCH signaling, which is upregulated in many forms of cancer.[2] The drug was initially developed by Roche for the treatment of Alzheimer's disease, but current research focuses on cancer.[3] Production was halted in 2010, but began again in 2014.[4]
Over 35 phase I and II clinical trials have been performed, but no phase III trials have yet commenced.[5] Phase II studies have investigated the use of RO4929097 in ovarian cancer,[6] renal cell carcinoma in patients that were unsuccessful on anti-VEGF treatments,[7] metastatic pancreatic cancer,[8] advanced brain tumors,[9] and relapsed non-small cell lung cancer.[10]
Other planned clinical trials were terminated, because the drug became unavailable.[11]