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Contents

   



(Top)
  


1 See also  




2 References  













RU-24,969






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From Wikipedia, the free encyclopedia
  

RU-24,969
Identifiers

  • 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole

CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H16N2O
Molar mass228.295 g·mol−1
3D model (JSmol)

  • c3cc(OC)cc1c3[nH]cc1C=2CCNCC=2

  • InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3 ☒N

  • Key:KRVMLPUDAOWOGN-UHFFFAOYSA-N ☒N

 ☒NcheckY (what is this?)  (verify)

RU-24,969 is a chemical compound widely used in scientific studies. It is a selective agonist at the 5-HT1A and 5-HT1B receptors, with preference for the latter.[1] As with other 5-HT1B agonists such as CP-94,253, RU-24,969 has been found to increase the reinforcing properties of cocaine, suggesting a role for 5-HT1B receptors in cocaine addiction.[2]

See also[edit]

References[edit]

  1. ^ Doods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, Van Zwieten PA (1985). "Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity". Eur J Pharmacol. 112 (3): 363–370. doi:10.1016/0014-2999(85)90782-4. PMID 3160596.
  • ^ Parsons LH, Weiss F, Koob GF (December 1998). "Serotonin1B receptor stimulation enhances cocaine reinforcement". Journal of Neuroscience. 18 (23): 10078–89. doi:10.1523/JNEUROSCI.18-23-10078.1998. PMC 6793270. PMID 9822762.


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=RU-24,969&oldid=1211300652"
    Categories: 
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