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Ralph Dorfman

Ralph Isadore Dorfman (1911–1985) was a Jewish American biochemist. His work on metabolisminpharmacology and the use of steroid hormones contributed to the development of the combined oral contraceptive pill.^[1]

Dorfman was born in Chicago, Illinois.^[2] He received his bachelor's degree from the University of Illinois and a doctorate from the University of Chicago.^[1] After teaching at several institutions, including Yale University, he became a director at the Worcester Foundation for Experimental BiologyinShrewsbury, Massachusetts, which, during his 13-year tenure there, "became an international center for bioassays and the study of the chemistry, biochemistry, and biology of steroid hormones."^[2]

While working at the Worcester Foundation, Dorfman was a research consultant to the Syntex Corporation, starting in 1950. There he helped to develop the first publicly available birth control pill.^[2] In 1964, Dorfman joined Syntex full-time, eventually serving as president of Syntex Research in Palo Alto, California from 1973 to 1976.^[1] Dorfman's research also focused on treatments for cancer and rheumatoid arthritis and originated the reproductive biology concept of anti-estrogens and anti-androgens.^[2]

Late in his career, Dorfman returned to academia serving as a visiting professor in the Department of Molecular PharmacologyatStanford University, 1967–1973, and finally as a consulting professor until his death. In addition to his numerous papers, Dorfman was the author or editor of 14 books and founded the journal Steroids.^[3]

Dorfman died of complications of Parkinson's diseaseatEl Camino HospitalinMountain View, California, at the age of 74.^[1] His brother was Albert Dorfman,^[2] and his grandson is Barnaby Dorfman.

References[edit]

• "Ralph I. Dorfman" at National Academy of Sciences