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Ravuconazole

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Ravuconazole
Clinical data

ATC code	None
Identifiers
IUPAC name 4-[2-[(2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
CAS Number	182760-06-1^Y
PubChem CID	467825
ChemSpider	411041^N
UNII	95YH599JWV
ChEBI	CHEBI:143825
ChEMBL	ChEMBL294029^N
NIAID ChemDB	057176
CompTox Dashboard (EPA)	DTXSID40171329
Chemical and physical data
Formula	C₂₂H₁₇F₂N₅OS
Molar mass	437.47 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@@H](c1nc(-c2ccc(C#N)cc2)cs1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
InChI InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1^N Key:OPAHEYNNJWPQPX-RCDICMHDSA-N^N
^NY (what is this?) (verify)

Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, the development of which was discontinued in 2007.^[1] The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life.^[2] However, ravuconazole has limited activity against species of Fusarium, Scedosporium, and Zygomycetes.^[3]^[4]

References

[edit]

^ "Ravuconazole". AdisInsight. Springer Nature Switzerland AG. Retrieved 12 November 2017.

^ Pasqualotto AC, Denning DW. "Ravuconazole". The Aspergillus Website. Retrieved 18 February 2010.

^ Pasqualotto AC, Thiele KO, Goldani LZ (February 2010). "Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole". Current Opinion in Investigational Drugs. 11 (2): 165–174. PMID 20112166.