Brothers was drafted by the Colorado Rockies in the first round of the 2009 MLB draft, and he signed with the team on July 9.[6] He then spent the 2009 and 2010 seasons in the minor leagues.[7] In 2011, Brothers made his major league debut with the Rockies on June 6. He finished the season with a 1–2 win–loss record, a 2.88 earned run average (ERA), and 59 strikeouts in 40+2⁄3innings in the majors.[6] In 2012, he went 8–2 with a 3.86 ERA and 83 strikeouts in 67+2⁄3 innings.[6]
On June 14, 2014, in a 5–4 win over the San Francisco Giants, Brothers struck out all three batters of the eighth inning on nine total pitches, becoming the 71st pitcher in major-league history to throw an immaculate inning.[8] It was also the first immaculate inning in Rockies franchise history and the first at AT&T Park.[citation needed] In 2014, he went 4–6 with a 5.59 ERA and 55 strikeouts in 56+1⁄3 innings.[6]
On February 3, 2017, after not pitching in baseball in 2016, Brothers signed a minor league contract with the Atlanta Braves.[12] On June 29, the Braves promoted Brothers to the major leagues.[13] He made 27 appearances, accumulating an ERA of 7.23 in 23+2⁄3 innings. He agreed to a one-year deal with the Braves for the 2018 season in November 2017.[14] He was outrighted to the Gwinnett Stripers on April 25, 2018. He became a free agent at the end of the season.[15]
On December 17, 2018, Brothers signed a minor league contract with the New York Yankees.[16] He received an invitation to spring training in 2019 as a non-roster player in 2019.[17] He became a free agent following the 2019 season.[18]
On January 22, 2020, Brothers signed a minor league deal with the Chicago Cubs. On July 23, 2020, the Cubs selected Brothers to the 40-man and active rosters. On October 30, 2020, Brothers was outrighted off of the 40-man roster. Later in the offseason, Brothers re-signed with the Cubs organization on a minor league contract.[19] On March 28, 2021, Brothers was selected to the 40-man roster.[20] In 57 games for the Cubs, Brothers posted a 5.26 ERA/4.87 FIP, struck out 75 batters, and earned one save across 53 innings. He was outrighted by the team on November 5, 2021, and elected free agency.[21]
On December 1, 2021, Brothers signed a minor league contract with the Milwaukee Brewers.[22] He was assigned to the Triple-A Nashville Sounds to begin the 2022 season. Brothers struggled immensely to the tune of a 17.36 ERA in 7 appearances for Nashville before he was released by the Brewers on May 3, 2022.[23]
On February 9, 2023, Brothers announced his retirement from professional baseball via his Instagram.[24]
Brothers has one brother, Hunter, and one sister, Cortney. Hunter also pitched at Lipscomb and was drafted by the Rockies in the 30th round of the 2014 MLB draft, playing two seasons in the minor leagues.[25]
Brothers and his wife, Jill, have three sons and a daughter, and reside in Tennessee during the off-season.[26][27]
