Contents

RhoH

RHOH
Identifiers
Aliases	RHOH, ARHH, TTF, RhoH, ras homolog family member H
External IDs	OMIM: 602037; MGI: 1921984; HomoloGene: 3180; GeneCards: RHOH; OMA:RHOH - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14 Start 40,191,053 bp[1] End 40,246,967 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.1 Start 66,018,556 bp[2] End 66,054,043 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells lymph node appendix granulocyte thymus spleen blood epithelium of nasopharynx tonsil epithelium of colon Top expressed in thymus blood mesenteric lymph nodes spleen primary oocyte granulocyte secondary oocyte zygote subcutaneous adipose tissue bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase inhibitor activity nucleotide binding GTP binding kinase inhibitor activity protein binding GTPase activity protein kinase binding Cellular component cytosol plasma membrane cytoplasm membrane immunological synapse intracellular anatomical structure cell cortex cell projection Biological process regulation of small GTPase mediated signal transduction regulation of transcription, DNA-templated negative regulation of I-kappaB kinase/NF-kappaB signaling mast cell activation T cell differentiation negative regulation of phosphorylation negative regulation of GTPase activity small GTPase mediated signal transduction actin filament organization establishment or maintenance of cell polarity Rho protein signal transduction regulation of cell shape actin cytoskeleton organization negative regulation of kinase activity regulation of actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 399 74734 Ensembl ENSG00000168421 ENSMUSG00000029204 UniProt Q15669 Q9D3G9 RefSeq (mRNA) NM_001278359 NM_001278360 NM_001278361 NM_001278362 NM_001278363 NM_001278364 NM_001278365 NM_001278366 NM_001278367 NM_001278368 NM_001278369 NM_004310 NM_001081105 NM_001363454 RefSeq (protein) NP_001265288 NP_001265289 NP_001265290 NP_001265291 NP_001265292 NP_001265293 NP_001265294 NP_001265295 NP_001265296 NP_001265297 NP_001265298 NP_004301 NP_001074574 NP_001350383 Location (UCSC) Chr 4: 40.19 – 40.25 Mb Chr 5: 66.02 – 66.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.^[5] It is encoded by the gene RHOH.^[6]

Gene[edit]

Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.^[6]

Interactions[edit]

RhoH has been shown to interact with ARHGDIA.^[7][8]

References[edit]

Further reading[edit]

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.