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1 References  













Ro 04-6790






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From Wikipedia, the free encyclopedia
  

Ro 04-6790
Clinical data
ATC code
  • none
Identifiers

  • 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide

CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H16N6O2S
Molar mass308.36 g·mol−1
3D model (JSmol)

  • Nc2ccc(cc2)S(=O)(=O)Nc1cc(NC)nc(NC)n1

  • InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18)

  • Key:JELFWSXQTXRMAJ-UHFFFAOYSA-N

  (verify)

Ro 04-6790 is a drug, developed by Hoffmann–La Roche, which has applications in scientific research. It acts as a potent and selective receptor antagonist for the 5-HT6 serotonin receptor subtype, with little or no affinity at other receptors. In common with other drugs of this class,[1] Ro 04-6790 has nootropic effects in animals,[2] and reduces the amnesia produced by memory-impairing drugs such as dizocilpine[3] and scopolamine.[4]

References[edit]

  1. ^ Fone KC (November 2008). "An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function". Neuropharmacology. 55 (6): 1015–22. doi:10.1016/j.neuropharm.2008.06.061. PMID 18655798. S2CID 35522597.
  • ^ King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC (January 2009). "Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task". Psychopharmacology. 202 (1–3): 111–23. doi:10.1007/s00213-008-1334-1. PMID 18839151. S2CID 10826081.
  • ^ Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N (April 2008). "The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801". Behavioural Brain Research. 188 (2): 304–9. doi:10.1016/j.bbr.2007.11.010. PMID 18164078. S2CID 40183481.
  • ^ Woolley ML, Marsden CA, Sleight AJ, Fone KC (December 2003). "Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790" (PDF). Psychopharmacology. 170 (4): 358–67. doi:10.1007/s00213-003-1552-5. PMID 13680084. S2CID 25193679.


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Ro_04-6790&oldid=1190946077"
    Categories: 
    ●Drugs not assigned an ATC code
     ●Nootropics
     ●Aminopyrimidines
     ●5-HT6 antagonists
     ●Drugs developed by Hoffmann-La Roche
     ●Nervous system drug stubs
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     ●Short description matches Wikidata
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     ●Drugs with no legal status
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    ●This page was last edited on 20 December 2023, at 19:41 (UTC).
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