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1 References  













S-23 (drug)






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From Wikipedia, the free encyclopedia
  

S-23
Legal status
Legal status
Identifiers

  • (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide

CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H13ClF4N2O3
Molar mass416.76 g·mol−1
3D model (JSmol)

  • C[C@](COC1=CC(=C(C=C1)Cl)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O

  • InChI=1S/C18H13ClF4N2O3/c1-17(27,9-28-12-4-5-14(19)15(20)7-12)16(26)25-11-3-2-10(8-24)13(6-11)18(21,22)23/h2-7,27H,9H2,1H3,(H,25,26)/t17-/m0/s1 ☒N

  • Key:SSFVOEAXHZGTRJ-KRWDZBQOSA-N ☒N

 ☒NcheckY (what is this?)  (verify)

S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolictoandrogenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.[1][2]

References[edit]

  1. ^ Marhefka CA, Gao W, Chung K, Kim J, He Y, Yin D, et al. (February 2004). "Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators". Journal of Medicinal Chemistry. 47 (4): 993–8. doi:10.1021/jm030336u. PMC 2040239. PMID 14761201.
  • ^ Jones A, Chen J, Hwang DJ, Miller DD, Dalton JT (January 2009). "Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception". Endocrinology. 150 (1): 385–95. doi:10.1210/en.2008-0674. PMC 2630904. PMID 18772237.
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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=S-23_(drug)&oldid=1132201431"
    Categories: 
    ●Anilides
     ●Tertiary alcohols
     ●Chloroarenes
     ●Fluoroarenes
     ●Nitriles
     ●Phenol ethers
     ●Selective androgen receptor modulators
     ●Trifluoromethyl compounds
     ●Genito-urinary system drug stubs
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    ●This page was last edited on 7 January 2023, at 19:04 (UTC).
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