Contents

SAG (gene)

SAG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZWJ
Identifiers
Aliases	SAG, RP47, S-AG, S-antigen; retina and pineal gland (arrestin), S-antigen visual arrestin
External IDs	OMIM: 181031; MGI: 98227; HomoloGene: 455; GeneCards: SAG; OMA:SAG - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,307,816 bp[1] End 233,347,055 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 D|1 44.44 cM Start 87,731,402 bp[2] End 87,772,880 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens testicle left testis right testis caudate nucleus putamen monocyte granulocyte bone marrow mucosa of transverse colon Top expressed in neural layer of retina retinal pigment epithelium corneal stroma pineal gland epithelium of lens iris conjunctival fornix embryo ciliary body spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase inhibitor activity phosphoprotein binding opsin binding G protein-coupled receptor binding Cellular component cytosol photoreceptor inner segment photoreceptor outer segment membrane cell projection Biological process rhodopsin mediated signaling pathway regulation of rhodopsin mediated signaling pathway signal transduction cell surface receptor signaling pathway negative regulation of phosphoprotein phosphatase activity G protein-coupled receptor internalization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6295 20215 Ensembl ENSG00000281857 ENSG00000130561 ENSMUSG00000056055 UniProt P10523 P20443 RefSeq (mRNA) NM_000541 NM_009118 RefSeq (protein) NP_000532 NP_033144 Location (UCSC) Chr 2: 233.31 – 233.35 Mb Chr 1: 87.73 – 87.77 Mb PubMed search [3] [4]
Wikidata
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S-arrestin is a protein that in humans is encoded by the SAG gene.^[5][6]

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble proteininphotoreceptor cells that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsintotransducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.^[6]

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