Contents

SEC63

Protein-coding gene in the species Homo sapiens

SEC63
Identifiers
Aliases	SEC63, DNAJC23, ERdj2, PRO2507, SEC63L, SEC63 homolog, protein translocation regulator, PCLD2
External IDs	OMIM: 608648; MGI: 2155302; HomoloGene: 5220; GeneCards: SEC63; OMA:SEC63 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 107,867,756 bp[1] End 107,958,208 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B2|10 22.89 cM Start 42,637,492 bp[2] End 42,708,510 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon body of pancreas parotid gland stromal cell of endometrium bone marrow cells ganglionic eminence ventricular zone left ovary olfactory zone of nasal mucosa right ovary Top expressed in seminal vesicula parotid gland lacrimal gland neural layer of retina saccule ventricular zone left lobe of liver tail of embryo otic placode crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding signaling receptor activity Cellular component endoplasmic reticulum membrane cytosol integral component of membrane membrane endoplasmic reticulum Sec62/Sec63 complex Biological process IRE1-mediated unfolded protein response protein targeting to membrane liver development protein transport SRP-dependent cotranslational protein targeting to membrane multicellular organism aging renal system development nitrogen compound metabolic process posttranslational protein targeting to endoplasmic reticulum membrane posttranslational protein targeting to membrane, translocation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11231 140740 Ensembl ENSG00000025796 ENSMUSG00000019802 UniProt Q9UGP8 Q8VHE0 RefSeq (mRNA) NM_007214 NM_018529 NM_153055 NM_001359283 NM_001359284 NM_001359285 NM_001359286 RefSeq (protein) NP_009145 NP_694695 NP_001346212 NP_001346213 NP_001346214 NP_001346215 Location (UCSC) Chr 6: 107.87 – 107.96 Mb Chr 10: 42.64 – 42.71 Mb PubMed search [3] [4]
Wikidata
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Translocation protein SEC63 homolog is a protein that in humans is encoded by the SEC63 gene.^[5][6][7]

Function[edit]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.^[7]

Clinical significance[edit]

Mutations of this gene have been linked with autosomal dominant polycystic liver disease.^[8]

References[edit]

Further reading[edit]

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