26S proteasome complex subunit DSS1 is a protein that in humans is encoded by the SHFM1 gene.[4][5][6]
The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle.[6]
SHFM1 has been shown to interact with BRCA2.[7][8]
PDB gallery
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1iyj: STRUCTURE OF A BRCA2-DSS1 COMPLEX
1miu: Structure of a BRCA2-DSS1 complex
1mje: STRUCTURE OF A BRCA2-DSS1-SSDNA COMPLEX
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