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Sodium-dependent phosphate transport protein 2C

Protein-coding gene in the species Homo sapiens

SLC34A3
Identifiers
Aliases	SLC34A3, HHRH, NPTIIc, solute carrier family 34 member 3, NaP2b
External IDs	OMIM: 609826; MGI: 2159410; HomoloGene: 15444; GeneCards: SLC34A3; OMA:SLC34A3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,230,757 bp[1] End 137,236,555 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,118,910 bp[2] End 25,124,376 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube sural nerve pituitary gland anterior pituitary endothelial cell human kidney skin of hip olfactory zone of nasal mucosa gastric mucosa right frontal lobe Top expressed in right kidney human kidney embryo lumbar subsegment of spinal cord yolk sac epithelium of small intestine embryo ileum otic vesicle stria vascularis More reference expression data BioGPS n/a
Gene ontology Molecular function symporter activity sodium:phosphate symporter activity Cellular component integral component of membrane plasma membrane membrane vesicle cytoplasm brush border apical plasma membrane brush border membrane Biological process phosphate ion transport cellular phosphate ion homeostasis sodium ion transmembrane transport sodium-dependent phosphate transport sodium ion transport transmembrane transport ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 142680 142681 Ensembl ENSG00000198569 ENSMUSG00000006469 UniProt Q8N130 Q80SU6 RefSeq (mRNA) NM_001177316 NM_001177317 NM_080877 NM_080854 NM_001362748 RefSeq (protein) NP_001170787 NP_001170788 NP_543153 NP_543130 NP_001349677 Location (UCSC) Chr 9: 137.23 – 137.24 Mb Chr 2: 25.12 – 25.12 Mb PubMed search [3] [4]
Wikidata
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Sodium-dependent phosphate transport protein 2C is a protein that in humans is encoded by the SLC34A3 gene.^[5][6][7][8]

Function[edit]

SLC34A3 contributes to the maintenance of inorganic phosphate concentration at the kidney.^[8]

Interactions[edit]

SLC34A3 has been shown to interact with PDZK1.^[9]

Clinical Correlation[edit]

A mutation in the SLC34A3 gene has been known to cause the autosomal recessive condition hereditary hypophophatemic rickets with hypercalciuria. This gene is correlated closely with SLC34A1, an analogue sodium phosphate cotransporter protein. Symptoms include renal phosphate wasting in addition to increase levels of 1,25-dihydroxyvitamin D (yields the hypercalcuria).^[6]

See also[edit]

• SLC34A3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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