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SLIT3

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SLIT3

Identifiers

Aliases

SLIT3, MEGF5, SLIL2, SLIT1, Slit-3, slit2, slit guidance ligand 3

External IDs

OMIM: 603745; MGI: 1315202; HomoloGene: 2303; GeneCards: SLIT3; OMA:SLIT3 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q34-q35.1	Start	168,661,733 bp^[1]
Band	5q34-q35.1	End	169,301,139 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 A4	Start	35,012,051 bp^[2]
Band	11\|11 A4	End	35,599,334 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right coronary artery

popliteal artery

tibial arteries

saphenous vein

gallbladder

cardiac muscle tissue of right atrium

vena cava

subcutaneous adipose tissue

left coronary artery

right auricle

Top expressed in

belly cord

gastrula

genital tubercle

paramesonephric duct

ascending aorta

tail of embryo

lip

superior cervical ganglion

skin of external ear

cardiac muscle tissue of atrium

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	Roundabout binding calcium ion binding heparin binding
Cellular component	extracellular region mitochondrion extracellular space
Biological process	negative regulation of chemokine-mediated signaling pathway chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration cell differentiation negative chemotaxis Roundabout signaling pathway negative regulation of gene expression nervous system development multicellular organism development cellular response to hormone stimulus negative regulation of cell growth response to cortisol apoptotic process involved in luteolysis animal organ morphogenesis axon extension involved in axon guidance negative regulation of cell population proliferation axon guidance aortic valve morphogenesis atrioventricular valve morphogenesis ventricular septum morphogenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6586


20564

Ensembl


ENSG00000184347


ENSMUSG00000056427

UniProt


O75094


Q9WVB4

RefSeq (mRNA)


NM_003062 NM_001271946


NM_011412

RefSeq (protein)


NP_001258875 NP_003053


NP_035542

Location (UCSC)

Chr 5: 168.66 – 169.3 Mb

Chr 11: 35.01 – 35.6 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Slit homolog 3 protein is a protein that in humans is encoded by the SLIT3 gene.^[5]^[6]^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184347 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056427 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (July 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.

^ Itoh A, Miyabayashi T, Ohno M, Sakano S (November 1998). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Research. Molecular Brain Research. 62 (2): 175–86. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.

^ "Entrez Gene: SLIT3 slit homolog 3 (Drosophila)".

Further reading[edit]

Holmes GP, Negus K, Burridge L, Raman S, Algar E, Yamada T, Little MH (December 1998). "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis". Mechanisms of Development. 79 (1–2): 57–72. doi:10.1016/S0925-4773(98)00174-9. PMID 10349621. S2CID 6057216.

Little MH, Wilkinson L, Brown DL, Piper M, Yamada T, Stow JL (August 2001). "Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein". American Journal of Physiology. Cell Physiology. 281 (2): C486-95. doi:10.1152/ajpcell.2001.281.2.c486. PMID 11443047. S2CID 13258049.

Marillat V, Cases O, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chédotal A (January 2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain". The Journal of Comparative Neurology. 442 (2): 130–55. doi:10.1002/cne.10068. PMID 11754167. S2CID 24164570.

Little M, Rumballe B, Georgas K, Yamada T, Teasdale RD (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes". The International Journal of Developmental Biology. 46 (4): 385–91. PMID 12141424.

Jiang LQ, Wen SJ, Wang HY, Chen LY (July 2002). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertension Research. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.

Shi Y, Zhao X, Yu L, Tao R, Tang J, La Y, Duan Y, Gao B, Gu N, Xu Y, Feng G, Zhu S, Liu H, Salter H, He L (July 2004). "Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population". Genome Research. 14 (7): 1345–9. doi:10.1101/gr.1758204. PMC 442150. PMID 15231749.

Hammond R, Vivancos V, Naeem A, Chilton J, Mambetisaeva E, Mambitisaeva E, Andrews W, Sundaresan V, Guthrie S (October 2005). "Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain" (PDF). Development. 132 (20): 4483–95. doi:10.1242/dev.02038. PMID 16162649. S2CID 25081153.

Lin L, Isacson O (November 2006). "Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits". Stem Cells. 24 (11): 2504–13. doi:10.1634/stemcells.2006-0119. PMC 2613222. PMID 16840550.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

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