Contents

SMARCC2

Protein-coding gene in the species Homo sapiens

SMARCC2
Identifiers
Aliases	SMARCC2, BAF170, CRACC2, Rsc8, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2, CSS8
External IDs	OMIM: 601734; MGI: 1915344; HomoloGene: 2312; GeneCards: SMARCC2; OMA:SMARCC2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 56,162,359 bp[1] End 56,189,567 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,295,117 bp[2] End 128,326,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence left ovary right lobe of thyroid gland right ovary right hemisphere of cerebellum sural nerve body of uterus left lobe of thyroid gland canal of the cervix Top expressed in genital tubercle neural layer of retina primary visual cortex cerebellar cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell tail of embryo ventricular zone suprachiasmatic nucleus zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding transcription coactivator activity protein binding nucleosomal DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific histone binding Cellular component transcription repressor complex nucleoplasm nucleus SWI/SNF complex npBAF complex nBAF complex protein-containing complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated nervous system development positive regulation of transcription, DNA-templated nucleosome disassembly negative regulation of transcription, DNA-templated chromatin remodeling regulation of transcription by RNA polymerase II chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6601 68094 Ensembl ENSG00000139613 ENSMUSG00000025369 UniProt Q8TAQ2 Q6PDG5 RefSeq (mRNA) NM_001130420 NM_003075 NM_139067 NM_001330288 NM_001114096 NM_001114097 NM_198160 NM_001372395 RefSeq (protein) NP_001123892 NP_001317217 NP_003066 NP_620706 NP_001107568 NP_001107569 NP_937803 NP_001359324 Location (UCSC) Chr 12: 56.16 – 56.19 Mb Chr 10: 128.3 – 128.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SWI/SNF complex subunit SMARCC2 is a protein that in humans is encoded by the SMARCC2 gene.^[5][6][7]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene.^[7]

SMARCC2 has been shown to interact with BAZ1B^[8] and SMARCA4.^[9][10][11]

• FactorBook BAF170

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.