Jump to content
 







Main menu
    


Navigation  


●Main page
 ●Contents
 ●Current events
 ●Random article
 ●About Wikipedia
 ●Contact us
 ●Donate
  



Contribute  


●Help
 ●Learn to edit
 ●Community portal
 ●Recent changes
 ●Upload file
  







Search  

































●Create account

●Log in
 









●Create account
 ● Log in
  



Pages for logged out editors learn more  


●Contributions
 ●Talk
  


















Contents

   



(Top)
  


1 References  













SR 59230A






●العربية
 ●فارسی
 ●Српски / srpski
 ●Srpskohrvatski / српскохрватски
  
Edit links
  








●Article
 ●Talk
  
















●Read
 ●Edit
 ●View history
  







Tools
    


Actions  


●Read
 ●Edit
 ●View history
  



General  


●What links here
 ●Related changes
 ●Upload file
 ●Special pages
 ●Permanent link
 ●Page information
 ●Cite this page
 ●Get shortened URL
 ●Download QR code
 ●Wikidata item
  



Print/export  


●Download as PDF
 ●Printable version
  















Appearance
    

 





From Wikipedia, the free encyclopedia
  

SR 59230A
Names
Preferred IUPAC name

(2S)-1-(2-Ethylphenoxy)-3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino}propan-2-ol

Identifiers

CAS Number

3D model (JSmol)
ChEBI
ChemSpider

IUPHAR/BPS

PubChem CID
UNII

CompTox Dashboard (EPA)

  • InChI=1S/C21H27NO2/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3/t18-,20-/m0/s1 ☒N

    Key: VFDHMSXXELYMRW-ICSRJNTNSA-N ☒N

  • CCc1ccccc1OC[C@H](CN[C@H]2CCCc3c2cccc3)O

Properties

Chemical formula

 C21H27NO2
Molar mass 325.452 g·mol−1

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

☒N verify (what is checkY☒N ?)

Infobox references

SR 59230A is a selective antagonist of the beta-3 adrenergic receptor,[1][2][3] but was subsequently shown to also act at α1 adrenoceptors at high doses.[4] It has been shown to block the hyperthermia produced by MDMA in animal studies.[5]

References[edit]

  1. ^ Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes". Mol. Pharmacol. 49 (1): 7–14. PMID 8569714.
  • ^ Bellantuono V, Cassano G, Lippe C (August 2008). "The adrenergic receptor subtypes present in frog (Rana esculenta) skin". Comp. Biochem. Physiol. C. 148 (2): 160–4. doi:10.1016/j.cbpc.2008.05.001. PMID 18544474.
  • ^ Rickenbacher A, Seiler R, Honegger U, Shaw SG, Balsiger BM (January 2008). "Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation". Surgery. 143 (1): 94–102. doi:10.1016/j.surg.2007.06.034. PMID 18154937.
  • ^ Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B (April 2004). "Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery". J. Pharmacol. Exp. Ther. 309 (1): 137–45. doi:10.1124/jpet.103.061192. PMID 14718590. S2CID 394120.
  • ^ Bexis S, Docherty JR (April 2009). "Role of alpha(1)- and beta(3)-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse". British Journal of Pharmacology. 158 (1): 259–66. doi:10.1111/j.1476-5381.2009.00186.x. PMC 2795232. PMID 19422394.


    • Stub icon

    This article about an alcohol is a stub. You can help Wikipedia by expanding it.

  • t
  • e

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=SR_59230A&oldid=1072448316"
    Categories: 
    ●Beta blockers
     ●Phenol ethers
     ●Secondary alcohols
     ●1-Aminotetralins
     ●Alcohol stubs
     Hidden categories: 
    ●Articles without InChI source
     ●Articles without KEGG source
     ●Articles with changed EBI identifier
     ●Articles with changed ChemSpider identifier
     ●Articles with changed InChI identifier
     ●Articles containing unverified chemical infoboxes
     ●Articles with short description
     ●Short description matches Wikidata
     ●All stub articles
      


    ●This page was last edited on 17 February 2022, at 20:12 (UTC).
    ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.


    ●Privacy policy
    ●About Wikipedia
    ●Disclaimers
    ●Contact Wikipedia
    ●Code of Conduct
    ●Developers
    ●Statistics
    ●Cookie statement
    ●Mobile view


    Wikimedia Foundation
    Powered by MediaWiki