Founded in 1911 on the initiative of three gymnastics clubs of the termale town (The Bagni, Arte et Marte and Acqui Club), the U.S. Acqui experienced its most successful period in the years following the founding: came to play in the Campionato Nazionale 1914–15, the last stop before the championship. It spent the next decades in Division I and Serie C, after World War II took part in mostly lower tournaments.
In the 2011–12 season, Acqui finished in 15th place in Serie D Girone A.
In summer 2012 it was excluded from Covisod for lack of documentation for to play in 2012–13 Serie D.[2] On 23 August 2012, the club was admitted in surplus in Eccellenza Piedmont and Aosta Valley/B.[3][4] Finally it went bankrupt in 2017 and its assets were bought by a minor town club which became the new Acqui FC.
