Seis Manos

A death ritual to Santa Nucifera has the initiate, Jaimito, brand his hands and take a black powder. But before the ritual completes, he rampages and leaves taking the powder. In the small Mexican town of San Simon, orphan Domingo steals a mango and escapes Federale Garcia to a private home, where three foster siblings train. Domingo is invited to stay by Sifu Chiu with Isabela, Jésus, and 'Silencio'. Meanwhile, DEA Agent Brister is assigned to a Bi-National Task Force to intercept cartel, in the only Mexican town with no drugs. The next day, as Domingo leaves to repay a man he robbed, the trio go to find him while Sifu battles a demonified Jaimito; recognizing the brand on his hands, Sifu dies to keep Jaimito at bay. This fails as Jaimito kills many citizens in town, including Domingo and Balde's men who found him; the trio devastated upon returning home to find their father now dead. Brister witnesses Jaimito's rampage and works with Garcia to investigate the matter.

As the trio grieve over Chiu's death, Isabella buries Sifu and organizes his belongings, Jésus goes to drink in his sorrow, and Silencio seeks solace with his lover Lina. Despite Garcia's attempts to investigate, Brister's work ethic offends her, so he seeks out a "folk healer" for intel. After Isabella finds a tattoo on Chiu's upper back, she later finds his diary detailing his life, but is too busy to read it. Meanwhile, El Balde calls a meeting of all Jefes, who he has drink the blood from Santa Nucifera, sending them into frenzies to attack San Simon for the "hidden jefe". At the Dojo, Isabella and Jésus are attacked by the monster Jefes, and as they consume the corpse of one of their fallen, one Jefe regains his humanity and kills himself. After a moment with Lina, Silencio returns to the Dojo to aid his siblings; Remembering Jaimito's death, Isabella lures the monsters with Sifu's body into a storage of Dit da jow, and blows them all up along with most of the dojo hacienda.

Garcia and Brister seek Folk Healer Mama Garabina for answers, and using magic she sees El Balde. Garabina grants them protective totems to continue their investigation, and Brister and Garcia relate over their respective similarities. Later, Garabina has visions of El Balde: the boy Baldemar, who loved his mother, but imprisoned her dying self in the statue of Santa Nucifera. With their home destroyed, Isabella asks Padre Serrano to examine a demonic finger they found, but it destroys itself. Serrano invites the trio to stay the night, but Jésus later discovers Serrano is cartel, and believing he killed Chiu he tells his siblings. The trio confront Serrano; Brister is hit by a stray shot, but is saved by the totem he received. As Silencio corners Serrano, Isabella tries calming him, but Silencio still kills Serrano, fleeing from Garcia and Brister.

In jail, Jésus blames Isabela for their circumstance, while Garcia calls Lina about Silencio, who asks she run away with him. But Lina admits to dealing for Serrano, so a hurt Silencio races back to help his siblings. After Balde is informed of Serrano's death, he lures out Silencio by targeting his siblings. As Garcia, Brister, Isabela and Jésus work together, Balde gives Powder to two stray dogs to attack the precinct. While the group is surviving, town drunk Piojo defeats one of the dogs using a technique Jésus taught him. The other dog recognizes Isabela from when she fed him, so they repeat Piojo's method to revert the other dog. Upon exiting, Silencio had killed all the snipers, but Balde arrives and kills Piojo while thanking the trio for killing Serrano. Realizing Balde killed Chiu, Silencio savagely attacks with minimal damage against the powered Balde, who recognizes Silencio; distracting him long enough for Lina to run him into a building. As Balde regenerates, Garcia brings her car to evacuate them to safety.

Garabina drives to San Simon, as a vision shows her the mother of Balde, the witch who helped her kill her cobarde husband. In town, Balde recognizes Garabina, asking why his mother allowed her to see him last time. Arriving at Garabina's home, Brister calls the DEA who won't send help unless he can prove Balde's involvement, and the best place to scout Balde's actions is in the ruins of Chiu's dojo. There, they encounter Chiu's brother, Shifu Lo; Brister and Garcia see Balde's execution of the mayor, and race to save Garabina. Using Garabina's magic camera, they freeze Balde long enough to exfil Garabina, who informs Garcia of how to defeat Balde. From the Bai Si Ceremony, Lo becomes the trio's new Sifu, who teaches them to use the full force of their styles, and from meditation connects with Silencio to know his birth name.

Garabina dies and is buried on Dojo grounds, while Lo helps Garcia awake from her visions, which inform her where to save Alejandra, Balde's mother. As the group leaves, Lo kills Lina as he restores Chiu's journal to find what was taken from him years ago. In San Simon, Balde is contacted by someone over sat-phone, in which he ends their "partnership," and enslaves every child after killing all adults. When infiltrating Balde's hacienda compound, their cover is blown and a battle ensues; Brister recognizes an owl and kills it, severing Lo's spying on them. As Balde returns to the hacienda, he readies to kill Brister and confirms his boss works with him, but senses Alejandra's revival, with Isabela as her host. Alejandra tells a stunned Balde she will kill him.

In the reality between life and death, Isabela meets Chiu while Alejandra uses her body to battle Balde, who is more empowered by vials of Powder. As Alejandra uses Isabela's martial prowess against Balde, while Jésus remembers Balde is weak to fire, like the monster Jefes that attacked the Dojo. In Between, Isabela asks about Chiu's tattoo- a Peach Blossom representing Immortality, not like Balde's Lotus symbol. With his guidance, Isabela helps Alejandra remember Balde as her son, but as Silencio and Jesus manage to finally kill him, Alejandra becomes vengeful and furious. Garcia binds Alejandra with a spell she used from Garabina's memories, she remembers her totem and "sweeps" away Alejandra into her Lotus medallion. Meanwhile, Lo searches the Dojo ruins for what Chiu stole from him decades earlier, finding it hidden in a dead tree and attaining immortality from the divine fruit. Back together, the group returns to the Dojo, but Isabela believes Silencio should be arrested for all the death he had brought. Inside, Silencio finds Lina's body, and his rage turns his right eyebrow fully white. Lo reveals himself, and his true alignment.

Lo elaborates that Chiu was once his favorite pupil, having refined his bloodlust into being Lo's best assassin, but then he stole the source of Lo's immortality. He easily overwhelms them in a fight, impaling Garcia into a tree branch and stabbing Brister. Lo restrains Silencio, bringing him to the Empty Place and offers he serve him seeing his power, offering to teach him to be at peace of self; Silencio refuses, but is still taken away by Lo's forces. As word of Balde's death spreads, the San Simon orphans plan a rebellion and reclaim the town. Brister's boss, Larry, arrives at the Dojo to arrest Brister to cover up all of Balde's madness, even holding onto Alejandra's medallion from the hacienda. Waking up, Isabella, Jésus and Garcia leave for Garabina's hut to recover, and return to San Simon to mourn their dead. As Isabela and Jésus think how to get to China to save Silencio, the orphans offer Serrano's stockpile of money, while Garcia stays to rebuild the town, while in China, Silencio awakens at Lo's Temple.