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1 References  














Sercloremine






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From Wikipedia, the free encyclopedia
 


Sercloremine
Names
Preferred IUPAC name

4-(5-Chloro-1-benzofuran-2-yl)-1-methylpiperidine

Identifiers

CAS Number

3D model (JSmol)

ChemSpider

PubChem CID

UNII

CompTox Dashboard (EPA)

  • InChI=1S/C14H16ClNO/c1-16-6-4-10(5-7-16)14-9-11-8-12(15)2-3-13(11)17-14/h2-3,8-10H,4-7H2,1H3

    Key: FTKTZRKAVSDSRA-UHFFFAOYSA-N

  • CN1CCC(CC1)C2=CC3=C(O2)C=CC(=C3)Cl

Properties

Chemical formula

C14H16ClNO
Molar mass 249.74 g·mol−1

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Sercloremine (CGP-4718A), usually as the hydrochloride salt, is a drug which was developed in the 1980s and was formerly under investigation as an antidepressant, but was never marketed.[1][2] It acts as a selective, reversible inhibitor of monoamine oxidase A (RIMA) and serotonin reuptake inhibitor.[1][3]

References

[edit]
  1. ^ a b Luttinger D, Hlasta DJ (January 1987). "Antidepressant agents". In Hesp B, Bailey DM (eds.). Annual Reports in Medicinal Chemistry. Vol. 22. Academic Press. pp. 21–30 (25). ISBN 978-0-08-058366-2.
  • ^ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1801–. ISBN 978-0-412-46630-4.
  • ^ Delini-Stula A, Fischbach R, Gnirss F, Bures E, Pöldinger W (1985). "Early experience with CGP 4718 A (Sercloremine), a new selective and reversible MAO-A and 5-HT-uptake inhibitor, in the treatment of depressive patients". Drug Development Research. 6 (4): 371–384. doi:10.1002/ddr.430060409. ISSN 0272-4391. S2CID 85113482.

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  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Sercloremine&oldid=1119924714"

    Categories: 
    Reversible inhibitors of MAO-A
    Antidepressants
    Benzofurans
    Piperidines
    Chloroarenes
    Serotonin reuptake inhibitors
    Monoamine oxidase inhibitors
    Nervous system drug stubs
    Hidden categories: 
    Articles without EBI source
    Articles without KEGG source
    Articles containing unverified chemical infoboxes
    Articles with short description
    Short description matches Wikidata
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    This page was last edited on 4 November 2022, at 04:20 (UTC).

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