snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein[5] that in humans is encoded by the SNRNP70 gene.[6][7] snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease.[8][9] U1-70K co-localizes with Tauinneurofibrillary tanglesinAlzheimer's disease.
snRNP70 has been shown to interact with ASF/SF2,[10][11] SRPK1,[12][13] and ZRANB2.[14]
Antibodies towards snRNP70 are associated with mixed connective tissue disease.[15]
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snRNP |
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hnRNP |
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Other transcription |
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Translation |
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Vault ribonucleoprotein particles |
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Other |
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