Solid pseudopapillary tumour | |
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Other names | Solid pseudopapillary neoplasm, solid pseudopapillary tumour/neoplasm of the pancreas, Frantz's tumour |
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Cytopathology of solid pseudopapillary tumour/neoplasm with main findings that distinguish it from pancreatic endocrine neoplasms and acinar cell carcinomas.[1] Diff-Quik stain. | |
Specialty | Oncology |
Asolid pseudopapillary tumour is a low-grade malignant neoplasm of the pancreasofpapillary architecture that typically afflicts young women.[2]
Solid pseudopapillary tumours are often asymptomatic and are identified incidentally on imaging performed for unrelated reasons. Less often, they may cause abdominal pain. Solid pseudopapillary tumours tend to occur in women, and most often present in the third decade of life.[3]
The gold standard for diagnosing solid pseudopapillary tumour of the pancreas is cytopathology by endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) of the lesion.[4] After surgical excision, the tumor can undergo histopathology evaluation for cancer staging.
Solid pseudopapillary tumours are typically round, well-demarcated, measuring 2–17 cm in diameter (average 8 cm), with solid and cystic areas with hemorrhage on cut sections.[5]
Solid pseudopapillary tumours consist of solid sheets of cells that are focally dyscohesive. The cells in the lesion usually have uniform nuclei with occasional nuclear grooves, eosinophilic or clear cytoplasm and PAS positive eosinophilic intracytoplasmic globules.[6] Necrosis is usually present and, as cell death preferentially occurs distant from blood vessels, lead to the formation of pseudopapillae.[citation needed]
Solid pseudopapillary tumours show positive nuclear staining for beta catenin, as well as positive immunostaining for CD10, CD56, vimentin, alpha 1-antitrypsin, and neuron specific enolase; they are negative for chromogranin and pancreatic enzymes.[7][8]
In most cases, solid pseudopapillary tumours should be resected surgically, as there is a risk of malignancy (cancer).[citation needed]
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: CS1 maint: multiple names: authors list (link) Last author update: 4 March 2022
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: CS1 maint: multiple names: authors list (link) Last author update: 4 March 2022