Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.[1]: 625 [2]
Spindle cell lipoma is most frequently located in the upper back, shoulder, or posterior neck subcutaneous layer.[3] Nonetheless, reports of it occurring in the mediastinum, hypopharynx, larynx, anterior neck, suprasellar region, esophagus, nasal vestibule, tongue, floor of mouth, vallecula, parotid gland, and breast have been made.[4] The tumor is said to have an average diameter of 4 to 5 cm and is growing slowly. Usually, the tumor is painless and solitary.[3] There have been documented rare instances of numerous lesions, including family occurrences.[5]
The diagnosis of spindle cell lipoma is mainly made in conjunction with clinical presentation and after other malignant tumors have been ruled out using cytologic, histologic, and cytogenetic evidence.[6]
According to histology, the lesion is made up of tiny, homogeneous spindle cells and mature adipocytes combined with eosinophilic collagen bundles inside a myxoidstroma. According to immunohistochemical staining, the spindle cells are positive for CD34 but negative for S-100 protein.[3]
Ko, Jennifer S.; Daniels, Brianne; Emanuel, Patrick O.; Elson, Paul; Khachaturov, Vadim; McKenney, Jesse K.; Goldblum, John R.; Billings, Steven D. (2017). "Spindle Cell Lipomas in Women: A Report of 53 Cases". American Journal of Surgical Pathology. 41 (9): 1267–1274. doi:10.1097/PAS.0000000000000915. ISSN0147-5185. PMID28719462.
