Asuperficial acral fibromyxoma is a type of myxoma and is a rare cutaneous condition characterized by a mesenchymal neoplasm that typically occurs on the digits of middle-aged adults.[1]: 1817
Superficial acral fibromyxoma impacts the palm, heel, and ankle in addition to the acral regions, with a clear preference for the periungual and subungual regions of the fingers and toes.[2] It begins as a slow-growing, solitary nodule limited to the dermis and subcutaneous tissue, and it is typically painless.[3] They range in size from 0.6-5 cm.[4] Fifty percent of the cases involve the nails, exhibiting either onycholysisorhyperkeratosis.[5]
A histologic examination reveals stellate and spindled fibroblast-like cells proliferating moderately within a myxoid and/or collagenous matrix with prominent microvasculature.[7] There may be a hyperkeratotic overlaying epidermis.[8][9] The tumor cells are distributed in a focally fascicular and loose storiform pattern.[4] This tumor can be positively stained with CD34,[10]CD99, vimentin, and CD10.[7]
Superficial acral fibromyxoma has a benign course.[3] Though it is possible for the tumor to convert into a low-grade malignant tumor, no malignant transition has been documented till 2001.[10][11] There have been reports of 22–24% local recurrence rates.[4][12]
^ abcFetsch, John F.; Laskin, William B.; Miettinen, Markku (2001). "Superficial acral fibromyxoma: A clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes". Human Pathology. 32 (7). Elsevier BV: 704–714. doi:10.1053/hupa.2001.25903. ISSN0046-8177. PMID11486169.
^ abcdAshby-Richardson, Harty; Rogers, Gary S; Stadecker, Miguel J (2011-08-01). "Superficial Acral Fibromyxoma: An Overview". Archives of Pathology & Laboratory Medicine. 135 (8): 1064–1066. doi:10.5858/2009-0684-RSR1. ISSN0003-9985. PMID21810002.
^Meyerle, CPT Jon H; Keller, COL Richard A; Krivda, LTC Stephen J (2004). "Superficial acral fibromyxoma of the index finger". Journal of the American Academy of Dermatology. 50 (1). Elsevier BV: 134–136. doi:10.1016/s0190-9622(03)00761-8. ISSN0190-9622. PMID14699384.
^Kazakov, D.V.; Mentzel, T.; Burg, G.; Kempf, W. (2002). "Superficial Acral Fibromyxoma: Report of Two Cases". Dermatology. 205 (3). S. Karger AG: 285–288. doi:10.1159/000065853. ISSN1018-8665.
^Al-Daraji, Wael I; Miettinen, Markku (2008-10-10). "Superficial acral fibromyxoma: a clinicopathological analysis of 32 tumors including 4 in the heel". Journal of Cutaneous Pathology. 35 (11). Wiley: 1020–1026. doi:10.1111/j.1600-0560.2007.00954.x. ISSN0303-6987. PMID18537858.
