Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.[5][6]
TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][6] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.[7][8]
TAAR9 gene deletion in rats leads to significantly decreased low-density lipoprotein cholesterol levels in the blood.[9]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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| TAAR1 |
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| TAAR2 |
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| TAAR5 |
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† References for all endogenous human TAAR1 ligands are provided at List of trace amines
‡ References for synthetic TAAR1 agonists can be found at TAAR1 or in the associated compound articles. For TAAR2 and TAAR5 agonists and inverse agonists, see TAAR for references.
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