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Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene (i.e., TGFB2).
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TGF beta superfamily of ligands |
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TGF beta receptors (Activin, BMP, family) |
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Transducers/SMAD |
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Ligand inhibitors |
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Coreceptors |
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Other |
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Fibroblast |
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EGF-like domain |
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TGFβ pathway |
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Insulin/IGF/ Relaxin family |
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Platelet-derived |
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Vascular endothelial |
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Other |
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Type I |
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Type II |
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Type III |
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Unsorted |
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