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(Top) 1 Interactions 2 References 3 Further reading

TGS1

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TGS1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3EGI, 3GDH

Identifiers

Aliases

TGS1, NCOA6IP, PIMT, PIPMT, trimethylguanosine synthase 1

External IDs

OMIM: 606461; MGI: 2151797; HomoloGene: 32608; GeneCards: TGS1; OMA:TGS1 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q12.1	Start	55,773,446 bp^[1]
Band	8q12.1	End	55,826,445 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 A1\|4 1.99 cM	Start	3,574,875 bp^[2]
Band	4 A1\|4 1.99 cM	End	3,616,619 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

oocyte

secondary oocyte

Achilles tendon

nipple

tail of epididymis

pylorus

internal globus pallidus

renal medulla

corpus epididymis

Top expressed in

tail of embryo

condyle

cumulus cell

genital tubercle

ureter

primitive streak

pineal gland

renal corpuscle

fossa

abdominal wall

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	methyltransferase activity transferase activity RNA trimethylguanosine synthase activity protein binding RNA methyltransferase activity
Cellular component	cytoplasm Cajal body nucleoplasm nucleolus small nuclear ribonucleoprotein complex nucleus extracellular space cytosol
Biological process	regulation of transcription, DNA-templated transcription, DNA-templated spliceosomal snRNP assembly methylation 7-methylguanosine RNA capping 7-methylguanosine cap hypermethylation ribonucleoprotein complex biogenesis RNA methylation regulation of lipid metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


96764


116940

Ensembl


ENSG00000137574


ENSMUSG00000028233

UniProt


Q96RS0


Q923W1

RefSeq (mRNA)


NM_024831 NM_001317902 NM_001363184


NM_054089

RefSeq (protein)


NP_001304831 NP_079107 NP_001350113


NP_473430

Location (UCSC)

Chr 8: 55.77 – 55.83 Mb

Chr 4: 3.57 – 3.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.^[5]^[6]^[7]

Interactions[edit]

TGS1 has been shown to interact with:

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137574 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028233 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ ^a ^b Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (Aug 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc Natl Acad Sci U S A. 98 (18): 10380–5. Bibcode:2001PNAS...9810380Z. doi:10.1073/pnas.181347498. PMC 56969. PMID 11517327.

^ Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonné R (May 2002). "Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus". Mol Cell. 9 (4): 891–901. doi:10.1016/S1097-2765(02)00484-7. PMID 11983179.

^ "Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)".

^ ^a ^b ^c ^d Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.

^ Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (Sep 2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/s0006-291x(03)01514-6. PMID 12943661.

Further reading[edit]

Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.

Verheggen C, Lafontaine DL, Samarsky D, Mouaikel J, Blanchard JM, Bordonné R, Bertrand E (2002). "Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments". EMBO J. 21 (11): 2736–45. doi:10.1093/emboj/21.11.2736. PMC 126019. PMID 12032086.

Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. doi:10.4049/jimmunol.169.2.1102. PMID 12097419.

Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. Bibcode:2002PNAS...9911836S. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.

Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P, Gribben JG (2002). "Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX". Blood. 100 (6): 2123–31. doi:10.1182/blood-2002-02-0513. PMID 12200376.

Mouaikel J, Narayanan U, Verheggen C, Matera AG, Bertrand E, Tazi J, Bordonné R (2004). "Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron". EMBO Rep. 4 (6): 616–22. doi:10.1038/sj.embor.embor863. PMC 1319203. PMID 12776181.

Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/S0006-291X(03)01514-6. PMID 12943661.

Watkins NJ, Lemm I, Ingelfinger D, Schneider C, Hossbach M, Urlaub H, Lührmann R (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell. 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. hdl:11858/00-001M-0000-0012-EB89-8. PMID 15574333.

Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.

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