TRAF6 is a TRAF human protein.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.[5]
TRAF6 has been shown to interact with:
PDB gallery
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1lb4: TRAF6 apo structure
1lb5: TRAF6-RANK Complex
1lb6: TRAF6-CD40 Complex
2jmd: Solution Structure of the Ring Domain of Human TRAF6
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JAK-STAT |
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Growth factor receptor-bound protein |
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Other |
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Signaling pathway: TLR signaling pathway
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TLRs |
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Other receptors |
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Downstream signalling |
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Chemokine |
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CSF |
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Interferon |
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Interleukin |
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TGFβ |
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TNF |
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Others |
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