Jump to content
 







Main menu
    


Navigation  


●Main page
 ●Contents
 ●Current events
 ●Random article
 ●About Wikipedia
 ●Contact us
 ●Donate
  



Contribute  


●Help
 ●Learn to edit
 ●Community portal
 ●Recent changes
 ●Upload file
  







Search  

































●Create account

●Log in
 









●Create account
 ● Log in
  



Pages for logged out editors learn more  


●Contributions
 ●Talk
  


















Contents

   



(Top)
  


1 References  













TRPM4-IN-5






●Deutsch
  
Edit links
  








●Article
 ●Talk
  
















●Read
 ●Edit
 ●View history
  







Tools
    


Actions  


●Read
 ●Edit
 ●View history
  



General  


●What links here
 ●Related changes
 ●Upload file
 ●Special pages
 ●Permanent link
 ●Page information
 ●Cite this page
 ●Get shortened URL
 ●Download QR code
 ●Wikidata item
  



Print/export  


●Download as PDF
 ●Printable version
  















Appearance
    

 





From Wikipedia, the free encyclopedia
  

TRPM4-IN-5
Identifiers

  • 4-chloro-2-{[2-(2-chlorophenoxy)acetyl]amino}benzoic acid

CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC15H11Cl2NO4
Molar mass340.16 g·mol−1
3D model (JSmol)

  • C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl

  • InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)

  • Key:CVQCJPCMPGKEDH-UHFFFAOYSA-N

TRPM4-IN-5 is a drug which acts as a moderately potent but highly selective blocker of the TRPM4 ion channel, with an IC50 of 1.5μM.[1] It is protective against glutamate mediated neuronal excitotoxicity.[2]

References[edit]

  1. ^ Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, et al. (June 2018). "Identification of potent and selective small molecule inhibitors of the cation channel TRPM4". British Journal of Pharmacology. 175 (12): 2504–2519. doi:10.1111/bph.14220. PMC 6002741. PMID 29579323.
  • ^ Bianchi B, Smith PA, Abriel H (July 2018). "The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration". Molecular Brain. 11 (1): 41. doi:10.1186/s13041-018-0385-4. PMC 6042389. PMID 29996905.
    • Stub icon

    This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

  • t
  • e

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=TRPM4-IN-5&oldid=1203027128"
    Categories: 
    ●Pharmacology stubs
     ●Carboxylic acids
     ●Amides
     ●Chlorobenzene derivatives
     Hidden categories: 
    ●Articles with short description
     ●Short description matches Wikidata
     ●Articles without EBI source
     ●Chemical pages without DrugBank identifier
     ●Articles without KEGG source
     ●Articles without UNII source
     ●Drugs missing an ATC code
     ●Drugs with no legal status
     ●Articles containing unverified chemical infoboxes
     ●All stub articles
      


    ●This page was last edited on 4 February 2024, at 01:50 (UTC).
    ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.


    ●Privacy policy
    ●About Wikipedia
    ●Disclaimers
    ●Contact Wikipedia
    ●Code of Conduct
    ●Developers
    ●Statistics
    ●Cookie statement
    ●Mobile view


    Wikimedia Foundation
    Powered by MediaWiki