Transient receptor potential cation channel subfamily V member 5 is a calcium channel protein that in humans is encoded by the TRPV5 gene.[5][6][7]
The TRPV5 gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel, TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.[8]
Both TRPV5 and TRPV6 are expressed in kidney and intestinal epithelial cells.[9] TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+,[10] whereas TRPV6 is mainly expressed in the intestine.[9] The enzyme α-klotho increases kidney calcium reabsorption by stabilizing TPRV5.[9] Klotho is a beta-glucuronidase-like enzyme that activates TRPV5 by removal of sialic acid.[11]
Normally, about 95% to 98% of Ca2+ filtered from the blood by the kidney is reabsorbed by the kidney's renal tubule, mediated by TRPV5.[12] Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequential hyperparathyroidism, and bone loss.[13]
TRPV5 has been shown to interact with S100A10.[15]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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see also disorders |
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TRPA |
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TRPC |
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TRPM |
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TRPML |
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TRPP |
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TRPV |
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See also: Receptor/signaling modulators • Ion channel modulators |
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