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Talk:Isosorbide dinitrate

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How realistic is this report http://www.bbc.co.uk/news/uk-wales-north-east-wales-20874142 and is the hazard significant enough to warrant mention here? Andy Dingley (talk) 02:24, 2 January 2013 (UTC)[reply]

Nitrate tolerance can occur even after 24 hours of use. To avoid tolerance, patients are usually provided with 6-8 hours of nitrate free time every day, which will decrease the likelihood of tolerance development. The article could be misleading in mentioning development of tolerance after "long-term" use. Snikayin (talk) 00:18, 13 March 2016 (UTC)[reply]