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Talk:Protein dimer

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What does constitutively dimerizes mean?[edit]

I saw it used in a few papers and I'm new to biology. — Preceding unsigned comment added by 68.126.190.60 (talk) 15:20, 29 November 2011 (UTC)[reply]

What probably is meant by "constitutively dimerization" is a protein that dimerizes in the absence of a ligand such as a drug, hormone, peptide, etc. Many proteins such a GPCRs exist as monomers in an inactive state when not bound to a ligand. When a ligand binds to the protein, the protein then dimerizes and the dimer in turn induces some down stream changes in cell function. This type of protein is referred to as "inducible". In contrast, proteins that dimerize and exerts down stream changes in cell function in the absence of ligand is referred to as "constitutive". Boghog (talk) 20:47, 29 November 2011 (UTC)[reply]

are there disulfite bonds in reverse transcriptase, or not? it is not clear what is it example of. — Preceding unsigned comment added by 109.121.83.245 (talk) 19:48, 15 August 2012 (UTC)[reply]

 Fixed Thanks for pointing out the ambiguity which I have removed. HIV reverse transcriptase is a heterodimer that is not disulfide link. I add another example (the protein NEMO) that is disulfide linked. Boghog (talk) 21:04, 15 August 2012 (UTC)[reply]

I'm not so sure. 41.114.43.220 (talk) 11:31, 21 July 2022 (UTC)[reply]

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