| Estrogen | Form | Dose (mg) | Duration by dose (mg) | Refs | |
|---|---|---|---|---|---|
| EPD | CICD | ||||
| Estradiol | Aq. soln. | ? | – | <1 d | [1] |
| Oil soln. | 40–60 | – | 1–2 ≈ 1–2 d | [2][3] | |
| Aq. susp. | ? | 3.5 | 0.5–2 ≈ 2–7 d; 3.5 ≈ >5 d | [2][4][5][6][7] | |
| Microsph. | ? | – | 1 ≈ 30 d | [8][9] | |
| Estradiol benzoate | Oil soln. | 25–35 | – | 1.66 ≈ 2–3 d; 5 ≈ 3–6 d | [10][11] |
| Aq. susp. | 20 | – | 10 ≈ 16–21 d | [12][13][14] | |
| Emulsion | ? | – | 10 ≈ 14–21 d | [14][15] | |
| Estradiol dipropionate | Oil soln. | 25–30 | – | 5 ≈ 5–8 d | [10] |
| Estradiol valerate | Oil soln. | 20–30 | 5 | 5 ≈ 7–8 d; 10 ≈ 10–14 d; 40 ≈ 14–21 d; 100 ≈ 21–28 d |
[11][16] |
| Estradiol benz. butyrate | Oil soln. | ? | 10 | 10 ≈ 21 d | [17][18] |
| Estradiol cypionate | Oil soln. | 20–30 | – | 5 ≈ 11–14 d | [11] |
| Aq. susp. | ? | 5 | 5 ≈ 14–24 d | [19][20][21] | |
| Estradiol enanthate | Oil soln. | ? | 5–10 | 10 ≈ 20–30 d | [22][23][24] |
| Estradiol dienanthate | Oil soln. | ? | – | 7.5 ≈ >40 d | [25][26] |
| Estradiol undecylate | Oil soln. | ? | – | 10–20 ≈ 40–60 d; 25–50 ≈ 60–120 d |
[27][28] |
| Polyestradiol phosphate | Aq. soln. | 40–60 | – | 40 ≈ 30 d; 80 ≈ 60 d; 160 ≈ 120 d |
[29][30] |
| Estrone | Oil soln. | ? | – | 1–2 ≈ 2–3 d | [3][31] |
| Aq. susp. | ? | – | 0.1–2 ≈ 2–7 d | [32] | |
| Estriol | Oil soln. | ? | – | 1–2 ≈ 1–4 d | [3][33] |
| Polyestriol phosphate | Aq. soln. | ? | – | 50 ≈ 30 d; 80 ≈ 60 d | |
Notes and sources
Notes: All aqueous suspensions are of microcrystalline particle size. Estradiol production during the menstrual cycle is 30–640 µg/d (6.4–8.6 mg total per month or cycle). The vaginal epithelium maturation dosage of estradiol benzoateorestradiol valerate has been reported as 5 to 7 mg/week. An effective ovulation-inhibiting doseofestradiol undecylate is 20–30 mg/month. Sources: Main/General: [34][35][36][37][38][39][40][41][42] Miscellaneous: [43][44][45]
| |||||
Template documentationSupply: ALPHA ESTRADIOL, U.S.P. IN SESAME OIL—For intramuscular injection, 0.14 mg per cc, 0.28 mg per cc, and 0.7 mg per cc. Ampuls—1 cc—Boxes of 12, 25, 100. Vials, 30 cc—Boxes of 1, 6. (Chicago Pharmacal). ALPHA-ESTRADIOL, U.S.P. IN SUSPENSION—0.14 mg per cc, 0.28 mg per cc, and 0.7 mg per cc. Vials, 30 cc—Boxes of 1, 6. (Chicago Pharmacal).
The following dosages for estradiol in the form of aqueous suspension injected intramuscularly, or pellets implanted subcutaneously, are recommended by a leading maunfacturer: Menopausal syndrome.—In average cases, 1 mg. intramuscularly 2 or 3 times weekly for 2 or 3 weeks; in more severe cases, 1 to 1.5 mg. Thereafter dosage is reduced to the minimum requirement, usually within the range of 0.5 to 1 mg. of estradiol twice weekly.
ESTRONE Parenteral Dosage Forms ESTRONE INJECTABLE SUSPENSION USP Usual adult dose Atrophic vaginitis or Menopausal (vasomotor) symptoms or Vulvar atrophy—Intramuscular, 100 to 500 mcg (0.1 to 0.5 mg) two or three times a week, cyclically or continuously as appropriate. Estrogen deficiency, due to ovariectomy or Female hypogonadism or Primary ovarian failure—Intramuscular, 100 mcg (0.1 mg) to 1 mg a week, administered as a single dose or in divided doses, cyclically or continuously. A few patients may need doses of up to 2 mg a week.
Table: Composition: Oestradiol valerate. Preparation: Primogyn Depot. Form of application: i.m. Proliferation dose in mg: 20–30. Estimated duration of action following a single application in days: 12–14.
