Contents

Thiram

Thiram

Names
Preferred IUPAC name Dimethylcarbamothioic dithioperoxyanhydride
Identifiers
CAS Number	137-26-8 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:9495 N
ChemSpider	5256 N
ECHA InfoCard	100.004.806
KEGG	D06114 Y
PubChem CID	5455
UNII	0D771IS0FH Y
CompTox Dashboard (EPA)	DTXSID5021332
InChI InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3 N Key: KUAZQDVKQLNFPE-UHFFFAOYSA-N N InChI=1/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3 Key: KUAZQDVKQLNFPE-UHFFFAOYAK
SMILES CN(C)C(=S)SSC(=S)N(C)C
Properties
Chemical formula	C6H12N2S4
Molar mass	240.42 g·mol−1
Appearance	White to yellow crystalline powder
Odor	Characteristic[vague][1]
Density	1.29 g/cm3[1]
Melting point	155 to 156 °C (311 to 313 °F; 428 to 429 K)
Boiling point	decomposes[1]
Solubility in water	30 mg/L
Vapor pressure	0.000008 mmHg (20 °C)[1]
Pharmacology
ATC code	P03AA05 (WHO)
Hazards
Flash point	138 °C (280 °F)[2]
Lethal dose or concentration (LD, LC):
LD50 (median dose)	1350 mg/kg (mouse, oral) 210 mg/kg (rabbit, oral) 560 mg/kg (rat, oral)[3]
LC50 (median concentration)	500 mg/m3 (rat, 4 hr)[3]
NIOSH (US health exposure limits):
PEL (Permissible)	TWA 5 mg/m3[1]
REL (Recommended)	TWA 5 mg/m3[1]
IDLH (Immediate danger)	100 mg/m3[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Chemical compound

Thiram is the simplest thiuram disulfide and the oxidized dimer of dimethyldithiocarbamate. It is used as a fungicide, ectoparasiticide to prevent fungal diseases in seed and crops and similarly as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents and deer. It is effective against Stem gall of coriander, damping off, smut of millet, neck rot of onion, etc. Thiram has been used in the treatment of human scabies, as a sun screen and as a bactericide applied directly to the skin or incorporated into soap.^[4]

Thiram is also used as a sulfur source and secondary accelerator the sulfur vulcanization of rubbers.

Usage[edit]

Thiram was traditionally used in apple and wine farming. Since 2010 most thiram is applied to soybeans.

Chemical properties[edit]

Thiram is a type of sulfur fungicide. It has been found to dissolve completely in chloroform, acetone, and ether. It is available as dust, flowable, wettable powder, water-dispersible granules, and water suspension formulations and in mixtures with other fungicides.^[4]

Thiram is nearly immobile in clay soils or in soils of high organic matter. It is not expected to contaminate groundwater because of its in-soil half life of 15 days, in addition to its tendency to adhere to soil particles.^[5]

As a waste, thiram carries an EPA U244 code.

Toxicity[edit]

Thiram is moderately toxic by ingestion, but it is highly toxic if inhaled. Acute exposure in humans may cause headaches, dizziness, fatigue, nausea, diarrhea, and other gastrointestinal complaints.^[6]

Chronic or repeated exposure may cause sensitive skin, and it may have effects on the thyroid or liver.^[7]

References[edit]

External links[edit]

• Thiram in the Pesticide Properties DataBase (PPDB)