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Contents

   



(Top)
 


1 Synthesis  





2 References  





3 External links  














Triazolobenzodiazepine






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From Wikipedia, the free encyclopedia
 


Chemical structure of alprazolam, a common triazolobenzodiazepine

Triazolobenzodiazepines (TBZD) are a class of benzodiazepine (BZD) derivative pharmaceutical drugs. Chemically, they differ from other benzodiazepines by having an additional triazole ring fused to the diazepine ring. The triazole and diazepine rings share a nitrogen atom.

Examples include:

Synthesis[edit]

Synthesis of 1-methyltriazolobenzodiazepines (alprazolam type) is possible by heating 1,4-benzodiazepin-2-thiones with hydrazine and acetic acid in n-butanol under reflux.[1]

References[edit]

  1. ^ Hester JB, Duchamp DJ, Chidester CG (1971): "A synthetic approach to new 1,4-benzodiazepine derivatives." Tetrahedron Letters, Vol. 12, pp. 1609-1612.

External links[edit]


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