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A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Trimecaine
Names
IUPAC name
N 2 N 2 N 1
Systematic IUPAC name
2-(Diethylamino)-N
Other names
N 2 N 2 N
Identifiers
CAS Number
3D model (JSmol )
ChemSpider
ECHA InfoCard 100.009.535
EC Number
KEGG
MeSH
D014288
PubChem CID
UNII
CompTox Dashboard (EPA )
InChI=1S/C15H24N2O/c1-6-17(7-2)10-14(18 )16-15-12(4 )8-11(3 )9-13(15 )5/h8-9H,6-7,10H2,1-5H3,(H,16,18)
Key: GOZBHBFUQHMKQB-UHFFFAOYSA-N
CCN(CC )CC(=O)NC1=C(C=C(C=C1C)C)C
Properties
Chemical formula
C 15 H 24 N 2 O
Molar mass
248.36386
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Trimecaine (systematic name (2,4,6-trimethylphenylcarbamoylmethyl)diethylammonium chloride , chemical formula C 15 H 25 2 O ) is an organic compound used as a local anesthetic and cardial antiarrhythmic . It is white crystalline powder readily soluble in water and ethanol .[1] [2]
History [ edit ]
Trimecaine is probably a Czech discovery (in light of complex pharmacological and clinical evaluation and practical deployment) although its preparation was published by Löfgren in 1946.[2]
Action mechanism, pharmacokinetics [ edit ]
Like other local anesthetics belonging in the amide group trimecaine decreases the cell membrane permeability, causes depolarization and shortens the action potential .[3] biological half-life is ca. 90 minutes. 10% of trimecaine is excreted unchanged (90% as its metabolites). It passes through the hematoencephalic and placental barriers .[4]
Indication [ edit ]
Trimecaine has two main application fields. The first one is local anesthesia (topical, infiltrational, topical mucosal and inhalational, spinal and Bier's intravenous). It is used in concentrations 0.4 up to 4%, in some cases (e.g. in stomatology ) in mixtures with adrenaline . The other field is prophylaxis and therapy of ventriculous arrhythmia on myocardial infarction and in cardiosurgery . It is used also for prophylaxis of sympathetic reaction during tracheal intubations .[3] [4]
Contraindication [ edit ]
Trimecaine must not be used at hypersensitivity on amide anesthetics, hypervolemia , hypotension , cardial conduction defects, asystole , cardiogenic shock and malignant hyperthermia in anamnesis .[3] [4]
Adverse effects [ edit ]
Rarely allergic reactions may occur (from dermal or mucosal symptoms to anaphylactic shock ). At overdosing a toxical reaction arises - excitation, agitation , dishevelment , visual defects, buzzing in ears, muscle thrill to tremor , in more severe cases somnolence , hyporeflexia , breathing defects to apnea , convulsions .[3] [4]
References [ edit ]
^ a b Trimekain
^ a b c d Antiarytmika (Novák, M.) Archived 2007-08-10 at archive.today
^ a b c d MESOCAIN - Operativa Archived 2011-07-18 at the Wayback Machine
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Trimecaine&oldid=1153705259 " C a t e g o r i e s : ● L o c a l a n e s t h e t i c s ● A n t i a r r h y t h m i c a g e n t s ● A c e t a n i l i d e s ● D i e t h y l a m i n o c o m p o u n d s H i d d e n c a t e g o r i e s : ● W e b a r c h i v e t e m p l a t e a r c h i v e i s l i n k s ● W e b a r c h i v e t e m p l a t e w a y b a c k l i n k s ● A r t i c l e s w i t h o u t I n C h I s o u r c e ● A r t i c l e s w i t h o u t E B I s o u r c e ● E C H A I n f o C a r d I D f r o m W i k i d a t a ● A r t i c l e s c o n t a i n i n g u n v e r i f i e d c h e m i c a l i n f o b o x e s ● C h e m b o x i m a g e s i z e s e t ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a
● T h i s p a g e w a s l a s t e d i t e d o n 7 M a y 2 0 2 3 , a t 2 1 : 0 6 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
