Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.[5][6]
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]
USF2 has been shown to interact with USF1 (human gene),[7][8] PPRC1[9] and BRCA1.[10]
The USF2 gene is repressed by the microRNA miR-10a.[11]
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