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1 References  














Vorozole






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Vorozole
Clinical data
Other namesR-76713; Rizivor
ATC code
Pharmacokinetic data
BioavailabilityVery high
MetabolismHepatic
Elimination half-life8 hours
Identifiers
  • 6-[(4-Chlorophenyl)(1,2,4-triazol-1-yl)methyl]-1-methylbenzotriazole

CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H13ClN6
Molar mass324.77 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1)[C@@H](c2ccc3nnn(c3c2)C)n4ncnc4

 ☒NcheckY (what is this?)  (verify)

Vorozole (developmental code name R-76713; former tentative brand name Rizivor) is a triazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.[1]

References[edit]

  1. ^ Goss PE (1998). "Pre-clinical and clinical review of vorozole, a new third generation aromatase inhibitor" (PDF). Breast Cancer Research and Treatment. 49. 49 (Suppl 1): S59-65, discussion S73-7. doi:10.1023/a:1006052923468. PMID 9797019. S2CID 28231447.
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  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Vorozole&oldid=1211944829"

    Categories: 
    Aromatase inhibitors
    Benzotriazoles
    Chloroarenes
    Triazoles
    Antineoplastic and immunomodulating drug stubs
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    This page was last edited on 5 March 2024, at 11:00 (UTC).

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