| Xg blood group | |
|---|---|
Interpretation of antibody panel to detect patient antibodies towards the most relevant human blood group systems, including Xg.
Further information: Blood compatibility testing | |
| Identifiers | |
| Symbol | XG |
| Alt. symbols | PBDX |
| NCBI gene | 7499 |
| HGNC | 12806 |
| RefSeq | NM_175569 |
| Other data | |
| Locus | Chr. X p22.32 |
The XG antigen is a red blood cell surface antigen discovered in 1962.[1] by researchers at the MRC Blood Group Unit.[2]
The PBDX gene that encodes the antigen is located on the short arm of the X chromosome.[3][4] Since males normally have one X chromosome they are considered hemizygotes. Since women have two copies of the gene and could be heterozygotic for the presence or absence of the functioning gene they could (through the process of lyonisation) express the functioning protein on just some of their red blood cells.[citation needed]
| Population frequencies of Xa[5] | ||||||
|---|---|---|---|---|---|---|
| Population | Sample N |
Xg % | ||||
| Australian Aborigines | 352 | 79 | ||||
| Chinese, mainland | 171 | 60 | ||||
| North Europeans | 5,388 | 66 | ||||
| Indians, Bombay | 100 | 65 | ||||
| Israelis | 201 | 66 | ||||
| American Indians | 308 | 77 | ||||
| New-Guineans | 263 | 85 | ||||
| New York's Afro-Americans | 219 | 55 | ||||
| Sardinians | 322 | 76 | ||||
| Taiwan Chinese | 178 | 53 | ||||
| Taiwan Aborigines | 164 | 38 | ||||
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| General concepts |
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| Transfusion reactions and adverse effects |
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| Blood group systems |
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