Pascal attended and played college football at Old Dominion from 2014 to 2016.[4] In 2016, he helped lead Old Dominion to the Bahamas Bowl, their first bowl game in program history.[5] During the game, he gained 78 yards and scored a touchdown in the victory against Eastern Michigan.[6]
On September 4, 2017, Pascal was signed to the practice squad of the Tennessee Titans.[12] He was promoted to the active roster on September 20, 2017.[13] He was waived on September 23, 2017, and was re-signed to the practice squad.[14] He signed a reserve/future contract with the Titans on January 15, 2018.[15] He was waived on June 14, 2018.[16]
On June 15, 2018, Pascal was claimed off of waivers by the Indianapolis Colts.[17] He competed for a spot and made the 53-man roster.[18] In the Colts' season opener against the Cincinnati Bengals, Pascal had one reception for 18 yards to go along with two kick returns for 54 net yards.[19] On September 30, he scored his first NFL touchdown with a pass from Andrew Luck in an overtime loss to the Houston Texans.[20] In the 2018 season, he had 27 receptions for 268 yards and two touchdowns.[21] In the Divisional Round loss to the Kansas City Chiefs, Pascal scored a touchdown when he recovered a blocked punt in the endzone.[22]
On October 20, 2019, in Week 7 against the Texans, Pascal finished with 106 receiving yards and two touchdowns, marking the first time in his professional career with over 100 yards.[23]
In Week 13 against the Titans, Pascal caught seven passes for 109 yards in the 31–17 loss.[24] On December 30, 2019, Pascal was signed to a one-year extension through 2020.[25] Overall, Pascal finished the 2019 season with 41 receptions for 607 receiving yards and five receiving touchdowns.[26]
In Week 15 of the 2020 season against the Texans, Pascal recorded five catches for 79 yards and two touchdowns during the 27–20 win.[27] Pascal finished the 2020 regular season with 44 receptions for 629 receiving yards and five receiving touchdowns.[28] Pascal scored a receiving touchdown in the Colts 27–24 loss to the Buffalo Bills in the Wild Card Round.[29]
The Colts placed a second-round restricted free agent tender on Pascal on March 17, 2021.[30] He signed the one-year contract on April 19.[31] Pascal started the 2021 season with two receiving touchdowns in Week 1 against the Seattle Seahawks.[32] In the 2021 season, Pascal finished with 38 receptions for 384 receiving yards and three receiving touchdowns.[33]
On March 21, 2022, Pascal signed a one-year contract with the Philadelphia Eagles, reuniting him with his former Colts offensive coordinatorNick Sirianni, who is the Eagles head coach.[34] He originally chose to wear No. 11, but switched to number 3 when the Eagles acquired A. J. Brown.[35] In the 2022 season, Pascal appeared in 17 games and started two. He finished with 15 receptions for 150 receiving yards and one receiving touchdown, which came in Week 8 against the Pittsburgh Steelers.[36] Pascal reached Super Bowl LVII, but the Eagles lost 38–35 to the Chiefs. In the Super Bowl, Pascal had two catches for 11 yards.[37]
On March 20, 2023, Pascal signed a two-year, $4.5 million contract with the Arizona Cardinals.[38] He appeared in 14 games and started one in the 2023 season.[39]