Holthuizen was born 5 April 1999, the younger of two children, to Martina Holthuizen (née Jaroch) and Mark Holthuizen, a business executive.[2][3] She is of Polish and Dutch origin.[4] She has an older brother, Kai Timothy Holthuizen, who is a model and musician.
Holthuizen trained in ballet, hip hop, jazz, and folk dance.[4][1] She became familiar with social media when she was started creating online content for the dance academy she was enrolled in.[1] She attended the European Film Actor School from 2014 to 2017.[4][1]
Holthuizen began her career as a stage actress, performing in plays at the European Film Actor School including Die Möve, Die drei Schwestern, Blick zurück im Zorn, and Late Night Talk.[4] She is signed as a fashion model with Visage International Management.[5] Holthuizen dropped her last name, and goes by her first and middle names professionally, due to her last name being "difficult to pronounce".[1]
In 2015 she received an Audience Award at the Zürich Film Festival for her role in the short film Mein erstes Mal | Nicht mein letztes Mal, which she also directed.[4] Her major film debut was as Alina in the 2015 Swiss drama film Amateur Teens.[1][4] In 2017 Holthuizen had a lead supporting role as Gianna in Lisa Brühlmannthe's coming-of-age film Blue My Mind.[6][7][8] In 2018 she had a guest role in the British dark-comedy-drama television series Killing Eve.[4]
In 2018 she was nominated for Best Performance in a Supporting Role at the Swiss Film Awards and for the Best Actor Newcomer Award at the Braunschweig International Film Festival for her role as Gianna in Blue My Mind.[4][9] She attended the Cannes Film Festival in 2019.[10]
In 2020 Holthuizen had a supporting lead role as Amalindis in the Swiss television feature film Die Hexenprinzessin.[4][1] The film was released as part of ZDF's series Märchenperlen.[1]
With over 200,000 followers on Instagram, she is one of the most successful social media influencers in Switzerland.[1] She has spoken about the challenges of being in the influencing business in Schweizer Illustrierte'sFuture of Influencers series.[1]
Holthuizen speaks German, French, Czech, and English.[4] She is vegan.[1][7] During the COVID-19 pandemic in Switzerland, Holthuizen spoke out against proposals for a vaccine mandate, stating that she would "retire to a desert island" if a "vaccination certificate was introduced."[11] In early March 2024, Holthuizen became a mother.[12]
