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Contents

   



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1 References  





2 External links  














Zymosan






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Zymosan
Identifiers

CAS Number

ChemSpider
  • none
ECHA InfoCard 100.029.737 Edit this at Wikidata

CompTox Dashboard (EPA)

Properties

Chemical formula

(C6H10O5)x
Molar mass Variable

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

☒N verify (what is checkY☒N ?)

Infobox references

Zymosan is a beta-glucan with repeating glucose units connected by β-1,3-glycosidic linkages. It binds to TLR 2 and Dectin-1 (CLEC7A). Zymosan is a ligand found on the surface of fungi, like yeast. [1]

Zymosan is prepared from yeast cell walls and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels, suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection, suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action.[2]

References[edit]

  1. ^ Sato M, Sano H, Iwaki D, et al. (2003). "Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A". J. Immunol. 171 (1): 417–25. doi:10.4049/jimmunol.171.1.417. PMID 12817025.
  • ^ Zymosan A from Saccharomyces cerevisiae Merck KGaA
  • External links[edit]


    Retrieved from "https://en.wikipedia.org/w/index.php?title=Zymosan&oldid=1219838038"

    Category: 
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    This page was last edited on 20 April 2024, at 04:10 (UTC).

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