Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment
J Pineal Res. 1998 Oct;25(3):177-83.
doi: 10.1111/j.1600-079x.1998.tb00557.x.
Authors
G Jean-Louis 1, H von Gizycki, F Zizi
Affiliation
●1Department of Psychiatry, University of California, San Diego, USA. gjeanlouis@ucsd.edu
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PMID:
9745987
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DOI:
10.1111/j.1600-079x.1998.tb00557.x
Abstract
The effects of immediate-release melatonin on circadian rest-activity profiles, cognition, and mood were investigated in ten elderly individuals with self-reported sleep-wake disturbances. Melatonin (6 mg), administered 2 hr before habitual bedtime, enhanced the rest-activity rhythm and improved sleep quality as observed in a reduction in sleep onset latency and in the number of transitions from sleep to wakefulness. However, total sleep time was not significantly increased nor was wake within sleep significantly reduced. The ability to remember previously learned items improved along with a significant reduction in depressed moods. No side effects or contraindications were reported by any of our participants during the 10 day trials. These data suggest that melatonin can safely improve some aspects of sleep, memory, and mood in the elderly in short-term use.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Affect / drug effects*
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Aged
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Circadian Rhythm
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Cognition / drug effects*
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Cognition Disorders / drug therapy*
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Cross-Over Studies
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Double-Blind Method
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Female
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Humans
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Male
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Melatonin / therapeutic use*
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Sleep / drug effects*
Substances
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Melatonin
Grants and funding
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5 T32 DA07233-09/DA/NIDA NIH HHS/United States
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HL55983/HL/NHLBI NIH HHS/United States