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ALDH16A1

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Aldehyde dehydrogenase 16 family, member A1 also known as ALDH16A1 is an aldehyde dehydrogenase gene.

ALDH16A1

Identifiers

ALDH16A1, aldehyde dehydrogenase 16 family member A1

External IDs

OMIM: 613358; MGI: 1916998; HomoloGene: 34938; GeneCards: ALDH16A1; OMA:ALDH16A1 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.33	Start	49,453,225 bp^[1]
Band	19q13.33	End	49,471,050 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B3	Start	44,790,108 bp^[2]
Band	7\|7 B3	End	44,804,008 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

granulocyte

spleen

mucosa of transverse colon

canal of the cervix

ectocervix

apex of heart

right lobe of liver

body of pancreas

right adrenal gland

skin of leg

Top expressed in

duodenum

right kidney

proximal tubule

jejunum

granulocyte

epithelium of small intestine

crypt of lieberkuhn of small intestine

interventricular septum

internal carotid artery

ileum

More reference expression data

n/a

Gene ontology
Molecular function	oxidoreductase activity aldehyde dehydrogenase (NAD+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Cellular component	extracellular exosome membrane
Biological process	metabolism
Sources:Amigo / QuickGO

Species

Human

Mouse


126133


69748


ENSG00000161618


ENSMUSG00000007833


Q8IZ83


Q571I9

RefSeq (mRNA)


NM_001145396 NM_153329


NM_145954

RefSeq (protein)


NP_001138868 NP_699160


NP_666066

Location (UCSC)

Chr 19: 49.45 – 49.47 Mb

Chr 7: 44.79 – 44.8 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Clinical significance

Mutations in the SPG21 (ACP33/maspardin) gene are associated with the mast syndrome, a type of spastic paraplegia. The protein encoded by the SPG21 gene has been shown to interact with the ALDH16A1 enzyme.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161618 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007833 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Hanna MC, Blackstone C (January 2009). "Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1". Neurogenetics. 10 (3): 217–28. doi:10.1007/s10048-009-0172-6. PMC 5585778. PMID 19184135.

External links

Human ALDH16A1 genome location and ALDH16A1 gene details page in the UCSC Genome Browser.

Further reading

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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